TY - JOUR
T1 - Ion channels in mesangial cells
T2 - Function, malfunction, or fiction
AU - Ma, Rong
AU - Pluznick, Jennifer L.
AU - Sansom, Steven C.
PY - 2005/4
Y1 - 2005/4
N2 - Ion channels in glomerular mesangial cells from humans, rats, and mice have been studied by electrophysiological, molecular, and gene-knockout methods. Two channels, a large, Ca2+-activated K+ channel (BK) and a store-operated Ca2+ channel (SOCC), can be defined with respect to molecular structure and function. Human BK, comprised of a pore-forming α-subunit and an accessory β1-subunit, operate as Ca 2+-sensing feedback modulators of contractile tone. SOCC have also been characterized in a mouse cell line; they are comprised of molecules belonging to the transient receptor potential subfamily.
AB - Ion channels in glomerular mesangial cells from humans, rats, and mice have been studied by electrophysiological, molecular, and gene-knockout methods. Two channels, a large, Ca2+-activated K+ channel (BK) and a store-operated Ca2+ channel (SOCC), can be defined with respect to molecular structure and function. Human BK, comprised of a pore-forming α-subunit and an accessory β1-subunit, operate as Ca 2+-sensing feedback modulators of contractile tone. SOCC have also been characterized in a mouse cell line; they are comprised of molecules belonging to the transient receptor potential subfamily.
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U2 - 10.1152/physiol.00050.2004
DO - 10.1152/physiol.00050.2004
M3 - Review article
C2 - 15772299
AN - SCOPUS:18244378538
SN - 1548-9213
VL - 20
SP - 102
EP - 111
JO - Physiology
JF - Physiology
IS - 2
ER -