IQGAP1 is a phosphoinositide effector and kinase scaffold

Suyong Choi; Richard A. Anderson

doi:10.1016/j.jbior.2015.10.004

IQGAP1 is a phosphoinositide effector and kinase scaffold

Suyong Choi, Richard A. Anderson

Research output: Contribution to journal › Review article › peer-review

40 Scopus citations

Abstract

Phosphatidylinositol 4,5-bisphosphate (PI4,5P₂) is a lipid messenger that regulates a wide variety of cellular functions. The majority of cellular PI4,5P₂ is generated by isoforms of the type I phosphatidylinositol phosphate kinases (PIPKI) that are generated from three genes, and each PIPKI isoform has a unique distribution and function in cells. It has been shown that the signaling specificity of PI4,5P₂ can be determined by a physical association of PIPKs with PI4,5P₂ effectors. IQGAP1 is newly identified as an interactor of multiple isoforms of PIPKs. Considering the versatile roles of IQGAP1 in cellular signaling pathways, IQGAP1 may confer isoform-specific roles of PIPKs in distinct cellular locations. In this mini review, the emerging roles of PIPKs that are regulated by an association with IQGAP1 will be summarized. Focuses will be on cell migration, vesicle trafficking, cell signaling, and nuclear events.

Original language	English (US)
Pages (from-to)	29-35
Number of pages	7
Journal	Advances in Biological Regulation
Volume	60
DOIs	https://doi.org/10.1016/j.jbior.2015.10.004
State	Published - Jan 1 2016
Externally published	Yes

Keywords

Cell signaling
IQGAP
Phosphatidylinositol phosphate kinase
Phosphoinositide

ASJC Scopus subject areas

Molecular Medicine
Molecular Biology
Genetics
Cancer Research

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10.1016/j.jbior.2015.10.004

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title = "IQGAP1 is a phosphoinositide effector and kinase scaffold",

abstract = "Phosphatidylinositol 4,5-bisphosphate (PI4,5P2) is a lipid messenger that regulates a wide variety of cellular functions. The majority of cellular PI4,5P2 is generated by isoforms of the type I phosphatidylinositol phosphate kinases (PIPKI) that are generated from three genes, and each PIPKI isoform has a unique distribution and function in cells. It has been shown that the signaling specificity of PI4,5P2 can be determined by a physical association of PIPKs with PI4,5P2 effectors. IQGAP1 is newly identified as an interactor of multiple isoforms of PIPKs. Considering the versatile roles of IQGAP1 in cellular signaling pathways, IQGAP1 may confer isoform-specific roles of PIPKs in distinct cellular locations. In this mini review, the emerging roles of PIPKs that are regulated by an association with IQGAP1 will be summarized. Focuses will be on cell migration, vesicle trafficking, cell signaling, and nuclear events.",

keywords = "Cell signaling, IQGAP, Phosphatidylinositol phosphate kinase, Phosphoinositide",

author = "Suyong Choi and Anderson, {Richard A.}",

note = "Publisher Copyright: {\textcopyright} 2015 Elsevier Ltd.",

year = "2016",

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doi = "10.1016/j.jbior.2015.10.004",

language = "English (US)",

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T1 - IQGAP1 is a phosphoinositide effector and kinase scaffold

AU - Choi, Suyong

AU - Anderson, Richard A.

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Phosphatidylinositol 4,5-bisphosphate (PI4,5P2) is a lipid messenger that regulates a wide variety of cellular functions. The majority of cellular PI4,5P2 is generated by isoforms of the type I phosphatidylinositol phosphate kinases (PIPKI) that are generated from three genes, and each PIPKI isoform has a unique distribution and function in cells. It has been shown that the signaling specificity of PI4,5P2 can be determined by a physical association of PIPKs with PI4,5P2 effectors. IQGAP1 is newly identified as an interactor of multiple isoforms of PIPKs. Considering the versatile roles of IQGAP1 in cellular signaling pathways, IQGAP1 may confer isoform-specific roles of PIPKs in distinct cellular locations. In this mini review, the emerging roles of PIPKs that are regulated by an association with IQGAP1 will be summarized. Focuses will be on cell migration, vesicle trafficking, cell signaling, and nuclear events.

AB - Phosphatidylinositol 4,5-bisphosphate (PI4,5P2) is a lipid messenger that regulates a wide variety of cellular functions. The majority of cellular PI4,5P2 is generated by isoforms of the type I phosphatidylinositol phosphate kinases (PIPKI) that are generated from three genes, and each PIPKI isoform has a unique distribution and function in cells. It has been shown that the signaling specificity of PI4,5P2 can be determined by a physical association of PIPKs with PI4,5P2 effectors. IQGAP1 is newly identified as an interactor of multiple isoforms of PIPKs. Considering the versatile roles of IQGAP1 in cellular signaling pathways, IQGAP1 may confer isoform-specific roles of PIPKs in distinct cellular locations. In this mini review, the emerging roles of PIPKs that are regulated by an association with IQGAP1 will be summarized. Focuses will be on cell migration, vesicle trafficking, cell signaling, and nuclear events.

KW - Cell signaling

KW - IQGAP

KW - Phosphatidylinositol phosphate kinase

KW - Phosphoinositide

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DO - 10.1016/j.jbior.2015.10.004

M3 - Review article

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VL - 60

SP - 29

EP - 35

JO - Advances in Biological Regulation

JF - Advances in Biological Regulation

ER -

IQGAP1 is a phosphoinositide effector and kinase scaffold

Abstract

Keywords

ASJC Scopus subject areas

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