IRF4 and IRF8: Governing the virtues of B lymphocytes

Vipul Shukla, Runqing Lu

Research output: Contribution to journalReview articlepeer-review

21 Scopus citations

Abstract

Interferon regulatory factor 4 (IRF4) and IRF8 are critical regulators of immune system development and function. In B lymphocytes, IRF4 and IRF8 have been shown to control important events during their development and maturation including pre-B cell differentiation, induction of B cell tolerance pathways, marginal zone B cell development, germinal center reaction and plasma cell differentiation. Mechanistically, IRF4 and IRF8 are found to function redundantly to control certain stages of B cell development, but in other stages, they function nonredundantly to play distinct roles in B cell biology. In line with their essential roles in B cell development, deregulated expressions of IRF4 and IRF8 have been associated to the pathogenesis of several B cell malignancies and diseases. Recent studies have elucidated diverse transcriptional networks regulated by IRF4 and IRF8 at distinct B cell developmental stages and related malignancies. In this review we will discuss the recent advances for the roles of IRF4 and IRF8 during B cell development and associated diseases.

Original languageEnglish (US)
Pages (from-to)269-282
Number of pages14
JournalFrontiers in Biology
Volume9
Issue number4
DOIs
StatePublished - Aug 2014

Keywords

  • B cell development
  • B lymphocytes
  • IRF4
  • IRF8
  • leukemia and lymphoma
  • transcriptional regulation

ASJC Scopus subject areas

  • Biotechnology
  • Ecology, Evolution, Behavior and Systematics
  • Ecology
  • Genetics

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