@article{a8d6ee7011a84a9e8d32ac2b2f1248ba,
title = "Iron oxide nanoparticle-mediated radiation delivery for glioblastoma treatment",
abstract = "Radiotherapy is a mainstay adjunctive therapy for glioblastoma (GBM). Despite the outcome improvement achieved with radiation, GBM prognosis remains dismal. Here we introduce a tumor-targeted iron oxide nanoparticle (NP) that intensifies the energy transfer of conventional photon radiotherapy on a selective cellular basis. Several NPs were formulated with systematic architectural variation to study and optimize reactive oxygen species (ROS) production. Selected from this screening stage, a biocompatible tumor-targeted NP was tested in vitro using two models of GBM, and then in vivo, using an orthotopic human primary GBM xenograft mouse model. Animals that received intravenous NP before irradiation demonstrated a 3-fold reduction in tumor growth and a 2-fold increase in survival. Cellular damage was investigated using in vivo magnetic resonance spectroscopy, which demonstrated increased therapeutic cytotoxicity specific to the tumor mass. Our work presents a viable therapeutic strategy to improve radiation therapy for GBM.",
keywords = "Enhanced radiation therapy, Glioblastoma treatment, Iron oxide nanoparticles, Magnetic resonance spectroscopy, Radiosensitization",
author = "Chiarelli, {Peter A.} and Revia, {Richard A.} and Stephen, {Zachary R.} and Kui Wang and Kievit, {Forrest M.} and Jordan Sandhu and Meenakshi Upreti and Seokhwan Chung and Ellenbogen, {Richard G.} and Miqin Zhang",
note = "Funding Information: This work was partially supported by National Institutes of Health Grant NIH/NCI R01CA161953 . P.A.C, Z.R.S, R. R, F.M.K. and J. S acknowledge support through NCI training grant T32CA138312 . We thank Jeffery Schwartz for the use of the gamma irradiator. P.A.C. acknowledges the Otis Booth Foundation, the Wright Foundation, as well as generous philanthropic support. P.A.C. thanks Jennifer Cotter MD, and Debra Hawes MD (CHLA Neuropathology) for their assistance on histology/IHC interpretation. Part of this work was supported by an NIH Biomedical Research Support Shared Instrumentation grant ( S10RR029021 to 14T High Resolution Imaging [HRIM] Core Facility). We acknowledge the use of the equipment on NP characterization in Nanoengineering & Science Institute and Molecular Engineering & Science Institute supported by NSF (grant NNCI-1542101 ). Funding Information: This work was partially supported by National Institutes of Health Grant NIH/NCI R01CA161953. P.A.C, Z.R.S, R. R, F.M.K. and J. S acknowledge support through NCI training grant T32CA138312. We thank Jeffery Schwartz for the use of the gamma irradiator. P.A.C. acknowledges the Otis Booth Foundation, the Wright Foundation, as well as generous philanthropic support. P.A.C. thanks Jennifer Cotter MD, and Debra Hawes MD (CHLA Neuropathology) for their assistance on histology/IHC interpretation. Part of this work was supported by an NIH Biomedical Research Support Shared Instrumentation grant (S10RR029021 to 14T High Resolution Imaging [HRIM] Core Facility). We acknowledge the use of the equipment on NP characterization in Nanoengineering & Science Institute and Molecular Engineering & Science Institute supported by NSF (grant NNCI-1542101). Publisher Copyright: {\textcopyright} 2022 Elsevier Ltd",
year = "2022",
month = jun,
doi = "10.1016/j.mattod.2022.04.001",
language = "English (US)",
volume = "56",
pages = "66--78",
journal = "Materials Today",
issn = "1369-7021",
publisher = "Elsevier",
}