Is pathogenic humoral autoimmunity a Th1 response? Lessons from (for) myasthenia gravis

Balaji Balasa, Nora Sarvetnick

Research output: Contribution to journalComment/debate

34 Scopus citations

Abstract

Myasthenia gravis (MG) is mediated by autoantibodies to the nicotinic acetylcholine receptor (AChR). Although AChR-specific T cells are necessary for disease development, the role of cytokines is not clear. Here, Balaji Balasa and Nora Sarvetnick discuss the T helper 1 (Th1)/Th2 paradigm and emerging evidence that interferon γ (IFN-γ) and interleukin 12 (IL-12) are important in experimental autoimmune MG pathogenesis.

Original languageEnglish (US)
Pages (from-to)19-23
Number of pages5
JournalImmunology Today
Volume21
Issue number1
DOIs
StatePublished - Jan 1 2000

ASJC Scopus subject areas

  • Immunology

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