Ischemic optic neuropathy as a model of neurodegenerative disorder: A review of pathogenic mechanism of axonal degeneration and the role of neuroprotection

Saba Khalilpour, Shahrzad Latifi, Ghazaleh Behnammanesh, Amin Malik Shah Abdul Majid, Aman Shah Abdul Majid, Ali Tamayol

Research output: Contribution to journalReview article

7 Scopus citations

Abstract

Optic neuropathy is a neurodegenerative disease which involves optic nerve injury. It is caused by acute or intermittent insults leading to visual dysfunction. There are number of factors, responsible for optic neuropathy, and the optic nerve axon is affected in all type which causes the loss of retinal ganglion cells. In this review we will highlight various mechanisms involved in the cell loss cascades during axonal degeneration as well as ischemic optic neuropathy. These mechanisms include oxidative stress, excitotoxicity, angiogenesis, neuroinflammation and apoptosis following retinal ischemia. We will also discuss the effect of neuroprotective agents in attenuation of the negative effect of factors involve in the disease occurrence and progression.

Original languageEnglish (US)
Pages (from-to)430-441
Number of pages12
JournalJournal of the neurological sciences
Volume375
DOIs
StatePublished - Apr 15 2017

Keywords

  • Angiogenesis
  • Excitotoxicity
  • Ischemic optic neuropathy
  • Neuroinflammation
  • Neuroprotection
  • Oxidative stress

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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