TY - JOUR
T1 - Ischemic optic neuropathy as a model of neurodegenerative disorder
T2 - A review of pathogenic mechanism of axonal degeneration and the role of neuroprotection
AU - Khalilpour, Saba
AU - Latifi, Shahrzad
AU - Behnammanesh, Ghazaleh
AU - Majid, Amin Malik Shah Abdul
AU - Majid, Aman Shah Abdul
AU - Tamayol, Ali
N1 - Publisher Copyright:
© 2016
PY - 2017/4/15
Y1 - 2017/4/15
N2 - Optic neuropathy is a neurodegenerative disease which involves optic nerve injury. It is caused by acute or intermittent insults leading to visual dysfunction. There are number of factors, responsible for optic neuropathy, and the optic nerve axon is affected in all type which causes the loss of retinal ganglion cells. In this review we will highlight various mechanisms involved in the cell loss cascades during axonal degeneration as well as ischemic optic neuropathy. These mechanisms include oxidative stress, excitotoxicity, angiogenesis, neuroinflammation and apoptosis following retinal ischemia. We will also discuss the effect of neuroprotective agents in attenuation of the negative effect of factors involve in the disease occurrence and progression.
AB - Optic neuropathy is a neurodegenerative disease which involves optic nerve injury. It is caused by acute or intermittent insults leading to visual dysfunction. There are number of factors, responsible for optic neuropathy, and the optic nerve axon is affected in all type which causes the loss of retinal ganglion cells. In this review we will highlight various mechanisms involved in the cell loss cascades during axonal degeneration as well as ischemic optic neuropathy. These mechanisms include oxidative stress, excitotoxicity, angiogenesis, neuroinflammation and apoptosis following retinal ischemia. We will also discuss the effect of neuroprotective agents in attenuation of the negative effect of factors involve in the disease occurrence and progression.
KW - Angiogenesis
KW - Excitotoxicity
KW - Ischemic optic neuropathy
KW - Neuroinflammation
KW - Neuroprotection
KW - Oxidative stress
UR - http://www.scopus.com/inward/record.url?scp=85014035178&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85014035178&partnerID=8YFLogxK
U2 - 10.1016/j.jns.2016.12.044
DO - 10.1016/j.jns.2016.12.044
M3 - Review article
C2 - 28320183
AN - SCOPUS:85014035178
SN - 0022-510X
VL - 375
SP - 430
EP - 441
JO - Journal of the neurological sciences
JF - Journal of the neurological sciences
ER -