Isepamicin sulfate-induced sensorineural hearing loss in patients with the 1555 A→G mitochondrial mutation

Shin Ichi Usami, Satoko Abe, Tetsuya Tono, Shizuo Komune, William J. Kimberling, Hideichi Shinkawa

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

A mitochondrial mutation at nucleotide 1555 has been reported to be susceptible to aminoglycoside antibiotics as well as one of the causes of nonsyndromic sensorineural hearing loss, We herewith report 2 cases bearing the 1555 A→G mitochondrial mutation who had hearing loss after short-term exposure to the new aminoglycoside antibiotic, isepamicin sulfate. Even when using aminoglycoside antibiotics with milder side effects, careful attention the should be paid in applying them to patients with particular genetic backgrounds.

Original languageEnglish (US)
Pages (from-to)164-169
Number of pages6
JournalORL
Volume60
Issue number3
DOIs
StatePublished - May 1998

Keywords

  • Aminoglycoside
  • Genetics
  • Isepamicin sulfate
  • Mitochondria
  • Ototoxicity
  • Point mutation
  • Sensorineural hearing loss

ASJC Scopus subject areas

  • Otorhinolaryngology

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    Usami, S. I., Abe, S., Tono, T., Komune, S., Kimberling, W. J., & Shinkawa, H. (1998). Isepamicin sulfate-induced sensorineural hearing loss in patients with the 1555 A→G mitochondrial mutation. ORL, 60(3), 164-169. https://doi.org/10.1159/000027590