Islet regeneration in IFNγ transgenic mice

E. M. Jones, N. Sarvetnick

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


The adult pancreas is a developmentally stable organ with limited mitotic activity. This minimal mitotic activity proves critical in insulin- dependent diabetes mellitus (IDDM) since the pathogenesis is characterized by a selective and permanent destruction of islet β cells. The IFNγ transgenic mouse model of islet regeneration elucidates the differentiation pathway involved in the regeneration of functional β cells from ductal precursors and reveals the functional plasticity of the adult pancreas.

Original languageEnglish (US)
Pages (from-to)308-310
Number of pages3
JournalHormone and Metabolic Research
Issue number6
StatePublished - 1997
Externally publishedYes


  • Development
  • Duct Cell
  • Growth Factors
  • Pancreas
  • β Cell

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical


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