Islet regeneration in IFNγ transgenic mice

E. M. Jones; N. Sarvetnick

doi:10.1055/s-2007-979041

Islet regeneration in IFNγ transgenic mice

E. M. Jones, N. Sarvetnick

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The adult pancreas is a developmentally stable organ with limited mitotic activity. This minimal mitotic activity proves critical in insulin- dependent diabetes mellitus (IDDM) since the pathogenesis is characterized by a selective and permanent destruction of islet β cells. The IFNγ transgenic mouse model of islet regeneration elucidates the differentiation pathway involved in the regeneration of functional β cells from ductal precursors and reveals the functional plasticity of the adult pancreas.

Original language	English (US)
Pages (from-to)	308-310
Number of pages	3
Journal	Hormone and Metabolic Research
Volume	29
Issue number	6
DOIs	https://doi.org/10.1055/s-2007-979041
State	Published - 1997
Externally published	Yes

Keywords

Development
Duct Cell
Growth Factors
Pancreas
β Cell

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Biochemistry
Endocrinology
Clinical Biochemistry
Biochemistry, medical

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10.1055/s-2007-979041

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title = "Islet regeneration in IFNγ transgenic mice",

abstract = "The adult pancreas is a developmentally stable organ with limited mitotic activity. This minimal mitotic activity proves critical in insulin- dependent diabetes mellitus (IDDM) since the pathogenesis is characterized by a selective and permanent destruction of islet β cells. The IFNγ transgenic mouse model of islet regeneration elucidates the differentiation pathway involved in the regeneration of functional β cells from ductal precursors and reveals the functional plasticity of the adult pancreas.",

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AU - Jones, E. M.

AU - Sarvetnick, N.

PY - 1997

Y1 - 1997

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AB - The adult pancreas is a developmentally stable organ with limited mitotic activity. This minimal mitotic activity proves critical in insulin- dependent diabetes mellitus (IDDM) since the pathogenesis is characterized by a selective and permanent destruction of islet β cells. The IFNγ transgenic mouse model of islet regeneration elucidates the differentiation pathway involved in the regeneration of functional β cells from ductal precursors and reveals the functional plasticity of the adult pancreas.

KW - Development

KW - Duct Cell

KW - Growth Factors

KW - Pancreas

KW - β Cell

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M3 - Article

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AN - SCOPUS:0030611347

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EP - 310

JO - Hormone and Metabolic Research

JF - Hormone and Metabolic Research

IS - 6

ER -

Islet regeneration in IFNγ transgenic mice

Abstract

Keywords

ASJC Scopus subject areas

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