Isolation and characterization of viruses from natural outbreaks of reticuloendotheliosis in turkeys

P. S. Sarma, D. K. Jain, N. K. Mishra, M. L. Vernon, P. S. Paul, B. S. Pomeroy

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

The authors describe the in vitro isolation of type C RNA viruses from two outbreaks of a fatal neoplastic disease in turkeys diagnosed as reticuloendotheliosis. The virus had a density of 1.16 g/ml in sucrose gradients, had a DNA polymerase capable of using both endogenous and exogenous (synthetic) templates, and was infectious in vitro for turkey and chick cells. The culture propapgated virus was oncogenic for turkeys. The virus isolates were unrelated to avian leukemia virus and antigenically identical to reticuloendotheliosis virus (REV) strain T. Thus the studies suggest that REV is a causative agent of naturally occurring, fatal leukemia in turkeys.

Original languageEnglish (US)
Pages (from-to)1355-1359
Number of pages5
JournalUnknown Journal
Volume54
Issue number6
DOIs
StatePublished - 1975

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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