Isolation and structure of dolastatin 17

George R. Pettit, Jun Ping Xu, Fiona Hogan, Ronald L. Cerny

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

The unusual cyclodepsipeptide dolastatin 17 (1) was isolated from the Papua New Guinea sea hare Dolabella auricularia and found to contain a new acetylenic β-amino acid designated dolayne (Doy). Dolastatin 17 exhibited significant human cancer cell growth inhibitory activity (GI50 0.45-0.74 μg/mL range).

Original languageEnglish (US)
Pages (from-to)491-496
Number of pages6
JournalHeterocycles
Volume47
Issue number1
DOIs
StatePublished - 1998

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

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