Isolation and Structure of the Cytostatic Linear Depsipeptide Dolastatin 15

George R. Pettit, Yoshiaki Kamano, Claude Dufresne, Ronald L. Cerny, Cherry L. Herald, Jean M. Schmidt

Research output: Contribution to journalArticle

161 Scopus citations

Abstract

The Indian Ocean sea hare Dolabella auricularia has been found to contain a strongly cytostatic depsipeptide constituent designated dolastatin 15. The unusual depsipeptide was found to markedly inhibit growth of the P388 lymphocytic leukemia cell line with ED50= 0.0024 μg/mL. The structure was elucidated by employing primarily high-field (400-MHz) 2D NMR and high-resolution mass spectrometry.

Original languageEnglish (US)
Pages (from-to)6005-6006
Number of pages2
JournalJournal of Organic Chemistry
Volume54
Issue number26
DOIs
StatePublished - Dec 1 1989

ASJC Scopus subject areas

  • Organic Chemistry

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    Pettit, G. R., Kamano, Y., Dufresne, C., Cerny, R. L., Herald, C. L., & Schmidt, J. M. (1989). Isolation and Structure of the Cytostatic Linear Depsipeptide Dolastatin 15. Journal of Organic Chemistry, 54(26), 6005-6006. https://doi.org/10.1021/jo00287a003