Isolation and structure of the human cancer cell growth inhibitory cyclic decapeptides phakellistatins 7, 8 and 91,2

George R. Pettit; Jun ping Xu; Ann Christine Dorsaz; Michael D. Williams; Michael R. Boyd; Ronald L. Cerny

doi:10.1016/0960-894X(95)00219-J

Isolation and structure of the human cancer cell growth inhibitory cyclic decapeptides phakellistatins 7, 8 and 9^1,2

George R. Pettit, Jun ping Xu, Ann Christine Dorsaz, Michael D. Williams, Michael R. Boyd, Ronald L. Cerny

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

Phakellistatins 7-9 respresent the first cancer cell growth inhibitory (P388 ED₅₀ 3.0, 2.9 and 4.1 μg/mL respectively) cyclic decapeptides. Each was isolated from the Federated States of Micronesia (Chuuk) marine sponge Phakellia costata. The Federated States of Micronesia (Chuuk) marine sponge Phakellia costata has been found to contain (10^-5 and 10^-6% yields) three cancer cell line active (P388 ED₅₀ 3.0, 2.9 and 4.1 μg/mL respectively) cyclic decapeptides named phakellistatins 7 (1), 8 (2) and 9 (3). Phakellistatins 7-9 represent the first cancer cell growth inhibitory cyclic decapeptides isolated from a marine sponge.

Original language	English (US)
Pages (from-to)	1339-1344
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	5
Issue number	13
DOIs	https://doi.org/10.1016/0960-894X(95)00219-J
State	Published - Jul 6 1995

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/0960-894X(95)00219-J

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title = "Isolation and structure of the human cancer cell growth inhibitory cyclic decapeptides phakellistatins 7, 8 and 91,2 ",

abstract = "Phakellistatins 7-9 respresent the first cancer cell growth inhibitory (P388 ED50 3.0, 2.9 and 4.1 μg/mL respectively) cyclic decapeptides. Each was isolated from the Federated States of Micronesia (Chuuk) marine sponge Phakellia costata. The Federated States of Micronesia (Chuuk) marine sponge Phakellia costata has been found to contain (10-5 and 10-6% yields) three cancer cell line active (P388 ED50 3.0, 2.9 and 4.1 μg/mL respectively) cyclic decapeptides named phakellistatins 7 (1), 8 (2) and 9 (3). Phakellistatins 7-9 represent the first cancer cell growth inhibitory cyclic decapeptides isolated from a marine sponge.",

author = "Pettit, {George R.} and Xu, {Jun ping} and Dorsaz, {Ann Christine} and Williams, {Michael D.} and Boyd, {Michael R.} and Cerny, {Ronald L.}",

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year = "1995",

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doi = "10.1016/0960-894X(95)00219-J",

language = "English (US)",

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AU - Pettit, George R.

AU - Xu, Jun ping

AU - Dorsaz, Ann Christine

AU - Williams, Michael D.

AU - Boyd, Michael R.

AU - Cerny, Ronald L.

N1 - Funding Information: TackettM, s. DeniseN ielsen-Tacketatn, dM r. Lee Williams. The four sectort andemm asss pectrometwera s purchasewdi thf undsa wardedb y the formerN SF regionailn strumentatiopnr ogram(g rantC HE-8620177a)n d the Universityo f Nebraska-Lincoln.A dditionals upportw as providedb y the NSF BiologyD ivision(grant DIR-9017262)

PY - 1995/7/6

Y1 - 1995/7/6

N2 - Phakellistatins 7-9 respresent the first cancer cell growth inhibitory (P388 ED50 3.0, 2.9 and 4.1 μg/mL respectively) cyclic decapeptides. Each was isolated from the Federated States of Micronesia (Chuuk) marine sponge Phakellia costata. The Federated States of Micronesia (Chuuk) marine sponge Phakellia costata has been found to contain (10-5 and 10-6% yields) three cancer cell line active (P388 ED50 3.0, 2.9 and 4.1 μg/mL respectively) cyclic decapeptides named phakellistatins 7 (1), 8 (2) and 9 (3). Phakellistatins 7-9 represent the first cancer cell growth inhibitory cyclic decapeptides isolated from a marine sponge.

AB - Phakellistatins 7-9 respresent the first cancer cell growth inhibitory (P388 ED50 3.0, 2.9 and 4.1 μg/mL respectively) cyclic decapeptides. Each was isolated from the Federated States of Micronesia (Chuuk) marine sponge Phakellia costata. The Federated States of Micronesia (Chuuk) marine sponge Phakellia costata has been found to contain (10-5 and 10-6% yields) three cancer cell line active (P388 ED50 3.0, 2.9 and 4.1 μg/mL respectively) cyclic decapeptides named phakellistatins 7 (1), 8 (2) and 9 (3). Phakellistatins 7-9 represent the first cancer cell growth inhibitory cyclic decapeptides isolated from a marine sponge.

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Isolation and structure of the human cancer cell growth inhibitory cyclic decapeptides phakellistatins 7, 8 and 9^1,2

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