Isotopomeric polymorphism

Jun Zhou, Young Sik Kye, Gerard S. Harbison

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


The complex formed between 4-methylpyridine and pentachlorophenol (4MPPCP) crystallizes in a triclinic space group. If the same complex is synthesized from deuterated pentachlorophenol (4MPPCP-d1), it crystallizes in an entirely different monoclinic polymorph. Solid-state NMR of samples synthesized with a full range of deuteration levels, crystallized from solution or the melt, and in the presence or absence of seeds confirms that the isotopomers indeed have different thermodynamically stable crystal structures. The phenomenon is apparently due to very different hydrogen bond strengths between the two polymorphs.

Original languageEnglish (US)
Pages (from-to)8392-8393
Number of pages2
JournalJournal of the American Chemical Society
Issue number27
StatePublished - Jul 14 2004

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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