Iterative high-throughput polymorphism studies on acetaminophen and an experimentally derived structure for form III

Matthew L. Peterson, Sherry L. Morissette, Chris McNulty, Andrew Goldsweig, Paul Shaw, Martin LeQuesne, Julie Monagle, Nicolas Encina, Joseph Marchionna, Alasdair Johnson, Javier Gonzalez-Zugasti, Anthony V. Lemmo, Stephen J. Ellis, Michael J. Cima, Örn Almarsson

Research output: Contribution to journalArticlepeer-review

156 Scopus citations

Abstract

Three crystal forms of acetaminophen were prepared and characterized using a newly developed high-throughput crystallization platform, CrystalMax. The platform consists of design software, robotic sample dispensing and handling, and high-throughput microanalytics and is capable of running thousands of crystallizations in parallel using several different methods to drive supersaturation and subsequent crystallization. Additionally, structural models of the elusive third form of acetaminophen will be discussed on the basis of powder X-ray diffraction data. One structure suggested has a bilayer motif, held together by O-H⋯O(H) hydrogen bonds, and helps explain the difficulty associated with preparing this form from solution.

Original languageEnglish (US)
Pages (from-to)10958-10959
Number of pages2
JournalJournal of the American Chemical Society
Volume124
Issue number37
DOIs
StatePublished - Sep 18 2002

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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