Johne's disease, inflammatory bowel disease, and Mycobacterium paratuberculosis

Ofelia Chacon, Luiz E. Bermudez, Raúl G. Barletta

Research output: Contribution to journalReview articlepeer-review

213 Scopus citations


Johne's disease is a chronic diarrhea affecting all ruminants. Mycobacterium avium subsp. paratuberculosis (MAP), a slowly growing mycobacteria, is the etiologic agent. There is also a concern that MAP might be a causative agent of some cases of inflammatory bowel disease in humans, especially Crohn's disease. Food products including pasteurized bovine milk have been suggested as potential sources of human infection. This review addresses microbial factors that may contribute to its pathogenicity. In addition, the experimental evidence defining MAP as the cause of Johne's disease and the issues and controversies surrounding its potential pathogenic role in humans are discussed.

Original languageEnglish (US)
Pages (from-to)329-363
Number of pages35
JournalAnnual Review of Microbiology
StatePublished - 2004


  • Crohn's disease
  • Diarrhea
  • Granulomatous enteritis
  • Mycobacteria
  • Ruminants

ASJC Scopus subject areas

  • Microbiology


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