Juvenile myasthenia gravis

O. Carter Snead, John W. Benton, Donard Dwyer, Barbara J. Morley, George E. Kemp, Ronald J. Bradley, Shin J. Oh

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Abstract

We studied 32 children with myasthenia gravis over a period of 12 years. The mean age at onset was 7.7 years. Presentation was ocular in 63% of patients. Another major disease in addition to myasthenia occurred in 44% of patients; a seizure disorder was the most commonly associated disease. Serum IgG antibody to nicotinic acetylcholine receptor was present in 53% of patients and did not correlate with severity of disease or treatment. Medical management was effective in 63%; thymectomy was effective in only 28%. We conclude that myasthenia gravis appears commonly before age 10 and is associated with the risk of some disease other than hyperthyroidism. Serum IgG nicotinic acetylcholine receptor antibody is present less frequently than in normal adults, and vigorous medical management should be attempted before thymectomy.

Original languageEnglish (US)
Pages (from-to)732-739
Number of pages8
JournalNeurology
Volume30
Issue number7
StatePublished - Jul 1980

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ASJC Scopus subject areas

  • Clinical Neurology

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Snead, O. C., Benton, J. W., Dwyer, D., Morley, B. J., Kemp, G. E., Bradley, R. J., & Oh, S. J. (1980). Juvenile myasthenia gravis. Neurology, 30(7), 732-739.