TY - JOUR
T1 - Kaposi's sarcoma associated herpesvirus infection among female sex workers and general population women in Shanghai, China
T2 - A cross-sectional study
AU - Zhang, Tiejun
AU - Yang, Ying
AU - Yu, Feng
AU - Zhao, Yanping
AU - Lin, Feifei
AU - Minhas, Veenu
AU - Wood, Charles
AU - He, Na
N1 - Funding Information:
This study was supported by Doctoral Fund of Ministry of Education of China (Grant No. 20120071120050 to TZ), the Fundamental Research Funds for the Central Universities (10FX058), National Natural Science Foundation of China (grant No. 81161120407 to NH), the Shanghai Leading Disciplinary Project (grant No. 12GWZX0101) and the United States National Institutes of Health Fogarty International Center (grant No. D43 TW001492, RO1 CA75903 and P30 GM103509 to CW).
PY - 2014/2/5
Y1 - 2014/2/5
N2 - Background: Limited information on epidemiologic patterns of KSHV, with none focusing on heterosexual transmission, is available in mainland China. To clarify this, a cross-sectional study was conducted among a group of female sex workers (FSW) and general population women (GW) in Shanghai, China. Methods: An anonymous questionnaire interview was administrated among 600 FSW and 600 GW. Blood samples were collected and tested for antibodies to KSHV, HSV-2, HIV, syphilis and HBsAg. Correlates of KSHV and HSV-2 were examined using multiple logistic regression analysis. Results: None of the study participants were tested positive for HIV. The seroprevalence of KSHV, HSV-2, HBV and syphilis was 10.0%, 52.2%, 12.3% and 10.5%, respectively for FSW, and was 11.0%, 15.3%, 9.8% and 2.8%, respectively for GW. KSHV seropositivity was not associated with syphilis and HSV-2 infection as well as sexual practices among either FSW or GW. Nevertheless, HSV-2 infection among FSW was independently associated with being ever married (OR = 1.59; 95%CI: 1.04-2.45), >5 years of prostitution (OR = 2.06; 95%CI: 1.16-3.68) and being syphilis positive (OR = 2.65; 95%CI: 1.43-4.93). HSV-2 infection among GW was independently associated with an age of >35 years (OR = 2.29; 95%CI: 1.07-4.93), having had more than 2 sex partners in the prior 12 months (OR = 6.44; 95%CI: 1.67-24.93) and being syphilis positive (OR = 3.94; 95%CI: 1.38-11.23). A gradual increase of prevalence with the prostitution time group was also detected for HSV-2 and syphilis, but not for KSHV. Conclusions: KSHV is moderately and equivalently prevalent among FSW and GW. Heterosexual contact is not a predominant route for KSHV transmission among Chinese women.
AB - Background: Limited information on epidemiologic patterns of KSHV, with none focusing on heterosexual transmission, is available in mainland China. To clarify this, a cross-sectional study was conducted among a group of female sex workers (FSW) and general population women (GW) in Shanghai, China. Methods: An anonymous questionnaire interview was administrated among 600 FSW and 600 GW. Blood samples were collected and tested for antibodies to KSHV, HSV-2, HIV, syphilis and HBsAg. Correlates of KSHV and HSV-2 were examined using multiple logistic regression analysis. Results: None of the study participants were tested positive for HIV. The seroprevalence of KSHV, HSV-2, HBV and syphilis was 10.0%, 52.2%, 12.3% and 10.5%, respectively for FSW, and was 11.0%, 15.3%, 9.8% and 2.8%, respectively for GW. KSHV seropositivity was not associated with syphilis and HSV-2 infection as well as sexual practices among either FSW or GW. Nevertheless, HSV-2 infection among FSW was independently associated with being ever married (OR = 1.59; 95%CI: 1.04-2.45), >5 years of prostitution (OR = 2.06; 95%CI: 1.16-3.68) and being syphilis positive (OR = 2.65; 95%CI: 1.43-4.93). HSV-2 infection among GW was independently associated with an age of >35 years (OR = 2.29; 95%CI: 1.07-4.93), having had more than 2 sex partners in the prior 12 months (OR = 6.44; 95%CI: 1.67-24.93) and being syphilis positive (OR = 3.94; 95%CI: 1.38-11.23). A gradual increase of prevalence with the prostitution time group was also detected for HSV-2 and syphilis, but not for KSHV. Conclusions: KSHV is moderately and equivalently prevalent among FSW and GW. Heterosexual contact is not a predominant route for KSHV transmission among Chinese women.
KW - Female sex workers
KW - Herpes simplex virus
KW - Kaposi's sarcoma associated herpesvirus
KW - Seroprevalence
KW - Women
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U2 - 10.1186/1471-2334-14-58
DO - 10.1186/1471-2334-14-58
M3 - Article
C2 - 24498947
AN - SCOPUS:84893172343
VL - 14
JO - BMC Infectious Diseases
JF - BMC Infectious Diseases
SN - 1471-2334
IS - 1
M1 - 58
ER -