Abstract
In mammals, the KIBRA locus has been associated with memory performance and cognition by genome-wide single nucleotide polymorphism screening. Genetic studies in Drosophila and human cells have identified KIBRA as a novel regulator of the Hippo signaling pathway, which plays a critical role in human tumorigenesis. Recent studies also indicated that KIBRA is involved in other physiological processes including cell polarity, membrane/vesicular trafficking, mitosis and cell migration. At the biochemical level, KIBRA protein is highly phosphorylated by various kinases in epithelial cells. Here, we discuss the updates concerning the function and regulation of KIBRA in the brain and beyond.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1392-1399 |
| Number of pages | 8 |
| Journal | Cellular Signalling |
| Volume | 26 |
| Issue number | 7 |
| DOIs | |
| State | Published - Jul 2014 |
Keywords
- Cell migration
- Cell polarity
- Hippo pathway
- KIBRA
- Memory performance
- Phosphorylation
ASJC Scopus subject areas
- Cell Biology
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Zhang, L., Yang, S., Wennmann, D. O., Chen, Y., Kremerskothen, J., & Dong, J. (2014). KIBRA: In the brain and beyond. Cellular Signalling, 26(7), 1392-1399. https://doi.org/10.1016/j.cellsig.2014.02.023