KIBRA: In the brain and beyond

Lin Zhang, Shuping Yang, Dirk Oliver Wennmann, Yuanhong Chen, Joachim Kremerskothen, Jixin Dong

Research output: Contribution to journalReview article

32 Scopus citations

Abstract

In mammals, the KIBRA locus has been associated with memory performance and cognition by genome-wide single nucleotide polymorphism screening. Genetic studies in Drosophila and human cells have identified KIBRA as a novel regulator of the Hippo signaling pathway, which plays a critical role in human tumorigenesis. Recent studies also indicated that KIBRA is involved in other physiological processes including cell polarity, membrane/vesicular trafficking, mitosis and cell migration. At the biochemical level, KIBRA protein is highly phosphorylated by various kinases in epithelial cells. Here, we discuss the updates concerning the function and regulation of KIBRA in the brain and beyond.

Original languageEnglish (US)
Pages (from-to)1392-1399
Number of pages8
JournalCellular Signalling
Volume26
Issue number7
DOIs
StatePublished - Jul 2014

Keywords

  • Cell migration
  • Cell polarity
  • Hippo pathway
  • KIBRA
  • Memory performance
  • Phosphorylation

ASJC Scopus subject areas

  • Cell Biology

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    Zhang, L., Yang, S., Wennmann, D. O., Chen, Y., Kremerskothen, J., & Dong, J. (2014). KIBRA: In the brain and beyond. Cellular Signalling, 26(7), 1392-1399. https://doi.org/10.1016/j.cellsig.2014.02.023