KIBRA: In the brain and beyond

Lin Zhang; Shuping Yang; Dirk Oliver Wennmann; Yuanhong Chen; Joachim Kremerskothen; Jixin Dong

doi:10.1016/j.cellsig.2014.02.023

KIBRA: In the brain and beyond

Lin Zhang, Shuping Yang, Dirk Oliver Wennmann, Yuanhong Chen, Joachim Kremerskothen, Jixin Dong

Research output: Contribution to journal › Review article › peer-review

33 Scopus citations

Abstract

In mammals, the KIBRA locus has been associated with memory performance and cognition by genome-wide single nucleotide polymorphism screening. Genetic studies in Drosophila and human cells have identified KIBRA as a novel regulator of the Hippo signaling pathway, which plays a critical role in human tumorigenesis. Recent studies also indicated that KIBRA is involved in other physiological processes including cell polarity, membrane/vesicular trafficking, mitosis and cell migration. At the biochemical level, KIBRA protein is highly phosphorylated by various kinases in epithelial cells. Here, we discuss the updates concerning the function and regulation of KIBRA in the brain and beyond.

Original language	English (US)
Pages (from-to)	1392-1399
Number of pages	8
Journal	Cellular Signalling
Volume	26
Issue number	7
DOIs	https://doi.org/10.1016/j.cellsig.2014.02.023
State	Published - Jul 2014

Keywords

Cell migration
Cell polarity
Hippo pathway
KIBRA
Memory performance
Phosphorylation

ASJC Scopus subject areas

Cell Biology

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10.1016/j.cellsig.2014.02.023

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title = "KIBRA: In the brain and beyond",

abstract = "In mammals, the KIBRA locus has been associated with memory performance and cognition by genome-wide single nucleotide polymorphism screening. Genetic studies in Drosophila and human cells have identified KIBRA as a novel regulator of the Hippo signaling pathway, which plays a critical role in human tumorigenesis. Recent studies also indicated that KIBRA is involved in other physiological processes including cell polarity, membrane/vesicular trafficking, mitosis and cell migration. At the biochemical level, KIBRA protein is highly phosphorylated by various kinases in epithelial cells. Here, we discuss the updates concerning the function and regulation of KIBRA in the brain and beyond.",

keywords = "Cell migration, Cell polarity, Hippo pathway, KIBRA, Memory performance, Phosphorylation",

author = "Lin Zhang and Shuping Yang and Wennmann, {Dirk Oliver} and Yuanhong Chen and Joachim Kremerskothen and Jixin Dong",

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T2 - In the brain and beyond

AU - Zhang, Lin

AU - Yang, Shuping

AU - Wennmann, Dirk Oliver

AU - Chen, Yuanhong

AU - Kremerskothen, Joachim

AU - Dong, Jixin

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AB - In mammals, the KIBRA locus has been associated with memory performance and cognition by genome-wide single nucleotide polymorphism screening. Genetic studies in Drosophila and human cells have identified KIBRA as a novel regulator of the Hippo signaling pathway, which plays a critical role in human tumorigenesis. Recent studies also indicated that KIBRA is involved in other physiological processes including cell polarity, membrane/vesicular trafficking, mitosis and cell migration. At the biochemical level, KIBRA protein is highly phosphorylated by various kinases in epithelial cells. Here, we discuss the updates concerning the function and regulation of KIBRA in the brain and beyond.

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KW - Cell polarity

KW - Hippo pathway

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KW - Memory performance

KW - Phosphorylation

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