KIBRA: In the brain and beyond

Lin Zhang; Shuping Yang; Dirk Oliver Wennmann; Yuanhong Chen; Joachim Kremerskothen; Jixin Dong

doi:10.1016/j.cellsig.2014.02.023

KIBRA: In the brain and beyond

Lin Zhang, Shuping Yang, Dirk Oliver Wennmann, Yuanhong Chen, Joachim Kremerskothen, Jixin Dong

Research output: Contribution to journal › Review article › peer-review

38 Scopus citations

Abstract

In mammals, the KIBRA locus has been associated with memory performance and cognition by genome-wide single nucleotide polymorphism screening. Genetic studies in Drosophila and human cells have identified KIBRA as a novel regulator of the Hippo signaling pathway, which plays a critical role in human tumorigenesis. Recent studies also indicated that KIBRA is involved in other physiological processes including cell polarity, membrane/vesicular trafficking, mitosis and cell migration. At the biochemical level, KIBRA protein is highly phosphorylated by various kinases in epithelial cells. Here, we discuss the updates concerning the function and regulation of KIBRA in the brain and beyond.

Original language	English (US)
Pages (from-to)	1392-1399
Number of pages	8
Journal	Cellular Signalling
Volume	26
Issue number	7
DOIs	https://doi.org/10.1016/j.cellsig.2014.02.023
State	Published - Jul 2014

Keywords

Cell migration
Cell polarity
Hippo pathway
KIBRA
Memory performance
Phosphorylation

ASJC Scopus subject areas

Cell Biology

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10.1016/j.cellsig.2014.02.023

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title = "KIBRA: In the brain and beyond",

abstract = "In mammals, the KIBRA locus has been associated with memory performance and cognition by genome-wide single nucleotide polymorphism screening. Genetic studies in Drosophila and human cells have identified KIBRA as a novel regulator of the Hippo signaling pathway, which plays a critical role in human tumorigenesis. Recent studies also indicated that KIBRA is involved in other physiological processes including cell polarity, membrane/vesicular trafficking, mitosis and cell migration. At the biochemical level, KIBRA protein is highly phosphorylated by various kinases in epithelial cells. Here, we discuss the updates concerning the function and regulation of KIBRA in the brain and beyond.",

keywords = "Cell migration, Cell polarity, Hippo pathway, KIBRA, Memory performance, Phosphorylation",

author = "Lin Zhang and Shuping Yang and Wennmann, {Dirk Oliver} and Yuanhong Chen and Joachim Kremerskothen and Jixin Dong",

note = "Funding Information: We thank Dr. Joyce Solheim for critical reading and comments on the manuscript. Research in the laboratory of J.D. is supported in part by the National Institutes of Health grants P20 GM103489 and R01 GM109066 . L.Z. is a graduate student supported by fellowships from the University of Nebraska Medical Center Graduate Studies and China Scholarship Council.",

year = "2014",

month = jul,

doi = "10.1016/j.cellsig.2014.02.023",

language = "English (US)",

volume = "26",

pages = "1392--1399",

journal = "Cellular Signalling",

issn = "0898-6568",

publisher = "Elsevier Inc.",

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T1 - KIBRA

T2 - In the brain and beyond

AU - Zhang, Lin

AU - Yang, Shuping

AU - Wennmann, Dirk Oliver

AU - Chen, Yuanhong

AU - Kremerskothen, Joachim

AU - Dong, Jixin

N1 - Funding Information: We thank Dr. Joyce Solheim for critical reading and comments on the manuscript. Research in the laboratory of J.D. is supported in part by the National Institutes of Health grants P20 GM103489 and R01 GM109066 . L.Z. is a graduate student supported by fellowships from the University of Nebraska Medical Center Graduate Studies and China Scholarship Council.

PY - 2014/7

Y1 - 2014/7

N2 - In mammals, the KIBRA locus has been associated with memory performance and cognition by genome-wide single nucleotide polymorphism screening. Genetic studies in Drosophila and human cells have identified KIBRA as a novel regulator of the Hippo signaling pathway, which plays a critical role in human tumorigenesis. Recent studies also indicated that KIBRA is involved in other physiological processes including cell polarity, membrane/vesicular trafficking, mitosis and cell migration. At the biochemical level, KIBRA protein is highly phosphorylated by various kinases in epithelial cells. Here, we discuss the updates concerning the function and regulation of KIBRA in the brain and beyond.

AB - In mammals, the KIBRA locus has been associated with memory performance and cognition by genome-wide single nucleotide polymorphism screening. Genetic studies in Drosophila and human cells have identified KIBRA as a novel regulator of the Hippo signaling pathway, which plays a critical role in human tumorigenesis. Recent studies also indicated that KIBRA is involved in other physiological processes including cell polarity, membrane/vesicular trafficking, mitosis and cell migration. At the biochemical level, KIBRA protein is highly phosphorylated by various kinases in epithelial cells. Here, we discuss the updates concerning the function and regulation of KIBRA in the brain and beyond.

KW - Cell migration

KW - Cell polarity

KW - Hippo pathway

KW - KIBRA

KW - Memory performance

KW - Phosphorylation

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DO - 10.1016/j.cellsig.2014.02.023

M3 - Review article

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AN - SCOPUS:84897088100

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EP - 1399

JO - Cellular Signalling

JF - Cellular Signalling

SN - 0898-6568

IS - 7

ER -

KIBRA: In the brain and beyond

Abstract

Keywords

ASJC Scopus subject areas

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