Kidney transplantation with rabbit antithymocyte globulin induction and sirolimus monotherapy

S. John Swanson, Douglas A. Hale, Roslyn B. Mannon, David E. Kleiner, Linda C. Cendales, Christine E. Chamberlain, Shirley M. Polly, David M. Harlan, Allan D. Kirk

Research output: Contribution to journalArticle

109 Scopus citations

Abstract

Renal allograft recipients generally need to take several immunosuppressive agents for life. Calcineurin inhibitors and glucocorticosteroids are the mainstays of most regimens but have undesirable chronic effects. We postulated that aggressive T-cell depletion combined with the newer immunosuppressant sirolimus would permit transplantation without multidrug treatment. We therefore tested T-cell depletion with rabbit antithymocyte globulin followed by sirolimus monotherapy in 12 patients in an open-label study. This approach was tolerated well, and all patients achieved excellent renal function, and most did not need chronic steroid treatment or calcineurin inhibitors. Rejection was typically correlated with low concentrations of sirolimus, indicating continued dependence on maintenance immunosuppression.

Original languageEnglish (US)
Pages (from-to)1662-1664
Number of pages3
JournalLancet
Volume360
Issue number9346
DOIs
StatePublished - Nov 23 2002

ASJC Scopus subject areas

  • Medicine(all)

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    Swanson, S. J., Hale, D. A., Mannon, R. B., Kleiner, D. E., Cendales, L. C., Chamberlain, C. E., Polly, S. M., Harlan, D. M., & Kirk, A. D. (2002). Kidney transplantation with rabbit antithymocyte globulin induction and sirolimus monotherapy. Lancet, 360(9346), 1662-1664. https://doi.org/10.1016/S0140-6736(02)11606-0