Kinetic modeling of metabolism: Present and future

Mohammad Mazharul Islam, Wheaton Lane Schroeder, Rajib Saha

Research output: Contribution to journalReview articlepeer-review

Abstract

Kinetic models of metabolism are predictors of temporal metabolic behavior of living organisms that integrate multi-omics data sets with reaction network models to interpret reaction rates, kinetic parameters, and enzyme levels. Modern kinetic modeling and parametrization frameworks are powerful tools for describing prokaryotic and eukaryotic metabolic behavior and promises successful application in human health, agriculture, and biotechnology. While the scarcity of in vivo data, computational expense, and scalability issues provide significant challenges, these can be circumvented by leveraging novel in silico data generation, training modules, and concerted effort from various fields of expertise.

Original languageEnglish (US)
Pages (from-to)72-78
Number of pages7
JournalCurrent Opinion in Systems Biology
Volume26
DOIs
StatePublished - Jun 2021

Keywords

  • Kinetic modeling
  • Metabolic model
  • Systems biology

ASJC Scopus subject areas

  • Modeling and Simulation
  • Biochemistry, Genetics and Molecular Biology(all)
  • Drug Discovery
  • Computer Science Applications
  • Applied Mathematics

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