KPC-4 is encoded within a truncated Tn4401 in an IncL/M plasmid, pNE1280, isolated from Enterobacter cloacae and Serratia marcescens

Kendall A. Bryant, Trevor C. Van Schooneveld, Ishwor Thapa, Dhundy Bastola, Laurina O. Williams, Thomas J. Safranek, Steven H. Hinrichs, Mark E. Rupp, Paul D. Fey

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

We describe the transfer of blaKPC-4 from Enterobacter cloacae to Serratia marcescens in a single patient. DNA sequencing revealed that KPC-4 was encoded on an IncL/M plasmid, pNE1280, closely related to pCTX-M360. Further analysis found that KPC-4 was encoded within a novel Tn4401 element (Tn4401f) containing a truncated tnpA and lacking tnpR, ISKpn7 left, and Tn4401 IRL-1, which are conserved in other Tn4401 transposons. This study highlights the continued evolution of Tn4401 transposons and movement to multiple plasmid backbones that results in acquisition by multiple species of Gram-negative bacilli.

Original languageEnglish (US)
Pages (from-to)37-41
Number of pages5
JournalAntimicrobial Agents and Chemotherapy
Volume57
Issue number1
DOIs
StatePublished - Jan 2013

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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