Abstract
The effectiveness of the cGMP-dependent protein kinase inhibitor, KT5823, was investigated in human neutrophils. KT5823 did not inhibit the cGMP-dependent protein kinase mediated in vitro, or in situ phosphorylation of vimentin, a known substrate for this enzyme in activated neutrophils. In addition, KT5823 was shown to induce dramatic shape changes in neutrophils, suggesting it has an activating effect upon the cells.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 3-14 |
| Number of pages | 12 |
| Journal | Research Communications in Chemical Pathology and Pharmacology |
| Volume | 74 |
| Issue number | 1 |
| State | Published - 1991 |
| Externally published | Yes |
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Toxicology
- Pharmacology
- Pharmacology, Toxicology and Pharmaceutics(all)