Laboratory diagnosis of tuberculosis requires a multimodality approach, as well as recognition that empiric therapy often is appropriate. New technologies such as proteomics and microarrays may soon find their place in the evaluation of patients.44,45 However, sputum and tissue analysis remain the cornerstone of laboratory diagnosis. Providers must be aware of how their laboratories process specimens, and which tests are an automatic part of evaluation. A direct PCR often must be requested separately.
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