Lack of a common or characteristic cytogenetic anomaly in solitary fibrous tumor

Alireza Torabi, Subodh M. Lele, Dominick DiMaio, Jeffrey C. Pinnt, Michelle M. Hess, Marilu Nelson, Julia A. Bridge

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Solitary fibrous tumor is a mesenchymal tumor that was initially described as a pleural-based lesion, but later was discovered in many other locations. The light-microscopic appearance of solitary fibrous tumor may overlap with other diagnostic entities; however, consistent tumor cell CD34 immunoreactivity is useful in establishing the diagnosis. Limited data suggest that solitary fibrous tumors are karyotypically diverse, and no common or characteristic anomaly has yet emerged for this entity. Cytogenetic analysis of two solitary fibrous tumors, one peritoneal and the other arising in the liver, revealed predominantly structural abnormalities in the former and numerical imbalances in the latter. Clonal karyotypic abnormalities were lacking in three additional solitary fibrous tumors.

Original languageEnglish (US)
Pages (from-to)60-64
Number of pages5
JournalCancer genetics and cytogenetics
Volume181
Issue number1
DOIs
StatePublished - Feb 2008

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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