Six patients with systemic sclerosis and internal organ involvement were randomized to receive total lymphoid irradiation (TLI) or to serve as untreated controls. Despite evidence of profound immunosuppression, were unable to detect any longlasting clinical benefit in the treated patients, with followups ranging from 1-4 years after TLI. Moreover, the results suggest that this therapy may accelerate pulmonary and gastrointestinal deterioration in scleroderma.
|Original language||English (US)|
|Number of pages||5|
|Journal||Journal of Rheumatology|
|State||Published - 1989|
ASJC Scopus subject areas
- Immunology and Allergy