Lack of clinical benefit after treatment of systemic sclerosis with total lymphoid irradiation

J. R. O'Dell, J. C. Steigerwald, R. C. Kennaugh, R. Hawkins, V. M. Holers, B. L. Kotzin

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Six patients with systemic sclerosis and internal organ involvement were randomized to receive total lymphoid irradiation (TLI) or to serve as untreated controls. Despite evidence of profound immunosuppression, were unable to detect any longlasting clinical benefit in the treated patients, with followups ranging from 1-4 years after TLI. Moreover, the results suggest that this therapy may accelerate pulmonary and gastrointestinal deterioration in scleroderma.

Original languageEnglish (US)
Pages (from-to)1050-1054
Number of pages5
JournalJournal of Rheumatology
Volume16
Issue number8
StatePublished - 1989

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

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