Lack of compartmentalization of HIV-1 quasispecies between the gut and peripheral blood compartments

Hiromi Imamichi, Gerald DeGray, Robin L. Dewar, Peter Mannon, Michael Yao, Cheryl Chairez, Irini Sereti, Joseph A. Kovacs

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

Compartmental differences in human immunodeficiency virus type 1 (HIV-1) between the gut and peripheral blood and within the gut were examined. Biopsy specimens from the colon and ileum and peripheral blood samples were collected from chronically HIV-1-infected individuals. HIV-1 envelope sequences were examined from cell-associated DNA and RNA and virion RNA. Phylogenetic analysis revealed no evidence of compartmentalization of HIV-1 between the gut and peripheral blood and within the gut (colon and ileum). HIV-1 sequences detected in the gut were transcriptionally active and were also found in peripheral blood from matching time points, providing evidence of ongoing virus production in the gut and equilibrium of HIV-1 between the gut and peripheral blood compartments.

Original languageEnglish (US)
Pages (from-to)309-314
Number of pages6
JournalJournal of Infectious Diseases
Volume204
Issue number2
DOIs
StatePublished - Jul 15 2011

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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