Lack of utility of intestinal fatty acid binding protein levels in predicting intestinal allograft rejection

Stuart S. Kaufman, Elizabeth R. Lyden, William H. Marks, Josh Lieberman, Debra L. Sudan, Ira J. Fox, Byers W. Shaw, Simon P. Horslen, Alan N. Langnas

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Introduction. The enterocyte-specific protein, intestinal fatty acid binding protein (I-FABP), is detectable in serum only after intestinal injury. Previous studies in animals suggest that I-FABP might be a useful marker of intestinal allograft rejection. Materials and Methods. I-FABP was repetitively measured in nine intestinal transplant recipients and correlated with findings of surveillance endoscopy. Results. Average interval between I-FABP determination and biopsy was 3.4 days (SD=4.2 days). Average number of rejection episodes per patient totalled 1.6±1.2. General linear modeling demonstrated no tendency for increases in serum FABP to precede histologic graft rejection (P=0.263). Restriction of the analysis to I-FABP determinations 1 day before or on the day of biopsy failed to affect these results. Minor increases in I-FABP were often associated with histologically normal grafts, whereas rejection often occurred when I-FABP was not detectable. Discussion. Serum I-FABP levels do not predict clinical intestinal allograft rejection.

Original languageEnglish (US)
Pages (from-to)1058-1060
Number of pages3
JournalTransplantation
Volume71
Issue number8
DOIs
StatePublished - 2001

ASJC Scopus subject areas

  • Transplantation

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    Kaufman, S. S., Lyden, E. R., Marks, W. H., Lieberman, J., Sudan, D. L., Fox, I. J., Shaw, B. W., Horslen, S. P., & Langnas, A. N. (2001). Lack of utility of intestinal fatty acid binding protein levels in predicting intestinal allograft rejection. Transplantation, 71(8), 1058-1060. https://doi.org/10.1097/00007890-200104270-00008