Lack of Weight Gain Associated with Short-Term Astemizole Treatment

Mark J. Ellison; Ronnie D. Horner; Frank H. Lawler; James G. Jones

doi:10.1177/106002809002400703

Lack of Weight Gain Associated with Short-Term Astemizole Treatment

Mark J. Ellison, Ronnie D. Horner, Frank H. Lawler, James G. Jones

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2 Scopus citations

Abstract

The effect of treatment with astemizole for three weeks on weight was assessed in 44 patients with seasonal allergic rhinitis who participated in a randomized, double-blind, placebo-controlled clinical trial. Astemizole 10-mg tablets and identical placebo tablets were used. Compared with baseline, weight increased significantly in astemizole-treated patients (1.07 ± 1.39 kg; p = 0.0004); however, the mean change in weight in astemizole-treated patients was not statistically significantly different than that seen in placebo-treated patients (0.85 ± 1.68 kg). No relationship was found between changes in weight and age, sex, initial weight, percentage of obesity, and plasma astemizole concentrations.

Original language	English (US)
Pages (from-to)	682-684
Number of pages	3
Journal	Annals of Pharmacotherapy
Volume	24
Issue number	7-8
DOIs	https://doi.org/10.1177/106002809002400703
State	Published - 1990
Externally published	Yes

ASJC Scopus subject areas

Pharmacology (medical)

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title = "Lack of Weight Gain Associated with Short-Term Astemizole Treatment",

abstract = "The effect of treatment with astemizole for three weeks on weight was assessed in 44 patients with seasonal allergic rhinitis who participated in a randomized, double-blind, placebo-controlled clinical trial. Astemizole 10-mg tablets and identical placebo tablets were used. Compared with baseline, weight increased significantly in astemizole-treated patients (1.07 ± 1.39 kg; p = 0.0004); however, the mean change in weight in astemizole-treated patients was not statistically significantly different than that seen in placebo-treated patients (0.85 ± 1.68 kg). No relationship was found between changes in weight and age, sex, initial weight, percentage of obesity, and plasma astemizole concentrations.",

author = "Ellison, {Mark J.} and Horner, {Ronnie D.} and Lawler, {Frank H.} and Jones, {James G.}",

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AU - Ellison, Mark J.

AU - Horner, Ronnie D.

AU - Lawler, Frank H.

AU - Jones, James G.

PY - 1990

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N2 - The effect of treatment with astemizole for three weeks on weight was assessed in 44 patients with seasonal allergic rhinitis who participated in a randomized, double-blind, placebo-controlled clinical trial. Astemizole 10-mg tablets and identical placebo tablets were used. Compared with baseline, weight increased significantly in astemizole-treated patients (1.07 ± 1.39 kg; p = 0.0004); however, the mean change in weight in astemizole-treated patients was not statistically significantly different than that seen in placebo-treated patients (0.85 ± 1.68 kg). No relationship was found between changes in weight and age, sex, initial weight, percentage of obesity, and plasma astemizole concentrations.

AB - The effect of treatment with astemizole for three weeks on weight was assessed in 44 patients with seasonal allergic rhinitis who participated in a randomized, double-blind, placebo-controlled clinical trial. Astemizole 10-mg tablets and identical placebo tablets were used. Compared with baseline, weight increased significantly in astemizole-treated patients (1.07 ± 1.39 kg; p = 0.0004); however, the mean change in weight in astemizole-treated patients was not statistically significantly different than that seen in placebo-treated patients (0.85 ± 1.68 kg). No relationship was found between changes in weight and age, sex, initial weight, percentage of obesity, and plasma astemizole concentrations.

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Lack of Weight Gain Associated with Short-Term Astemizole Treatment

Abstract

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