Abstract
Lambert-Eaton syndrome (LES) is an immune-mediated disorder of the presynaptic neuromuscular junction due to the blocking effect of the voltage-gated calcium channel (VGCC) antibodies. Small-cell lung cancer (SCLC) is the most common cause of LES. We report an unusual case of LES associated with large-cell neuroendocrine carcinoma (LCNEC) of the lung. In this case, clinical symptoms of LES predated the diagnosis of LCNEC by 6 years. After tumor resection, the patient experienced clinical and electrophysiological improvement. In addition, he had a decrease in VGCC antibody titer from 130 to 80 pmol/L. The onset of LES can be prolonged, and tumor surveillance should continue in these cases.
Original language | English (US) |
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Pages (from-to) | 786-789 |
Number of pages | 4 |
Journal | Muscle and Nerve |
Volume | 37 |
Issue number | 6 |
DOIs | |
State | Published - Jun 2008 |
Externally published | Yes |
Keywords
- Lambert-Eaton
- Neuroendocrine carcinoma nerve conduction
- Repetitive nerve stimulation
ASJC Scopus subject areas
- Physiology
- Clinical Neurology
- Cellular and Molecular Neuroscience
- Physiology (medical)