Lambert-Eaton syndrome with large-cell neuroendocrine carcinoma of the lung

Christian Grommes; David C. Preston; Zaid Al-Kadhimi; Amer Alshekhlee

doi:10.1002/mus.21032

Lambert-Eaton syndrome with large-cell neuroendocrine carcinoma of the lung

Christian Grommes, David C. Preston, Zaid Al-Kadhimi, Amer Alshekhlee

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Lambert-Eaton syndrome (LES) is an immune-mediated disorder of the presynaptic neuromuscular junction due to the blocking effect of the voltage-gated calcium channel (VGCC) antibodies. Small-cell lung cancer (SCLC) is the most common cause of LES. We report an unusual case of LES associated with large-cell neuroendocrine carcinoma (LCNEC) of the lung. In this case, clinical symptoms of LES predated the diagnosis of LCNEC by 6 years. After tumor resection, the patient experienced clinical and electrophysiological improvement. In addition, he had a decrease in VGCC antibody titer from 130 to 80 pmol/L. The onset of LES can be prolonged, and tumor surveillance should continue in these cases.

Original language	English (US)
Pages (from-to)	786-789
Number of pages	4
Journal	Muscle and Nerve
Volume	37
Issue number	6
DOIs	https://doi.org/10.1002/mus.21032
State	Published - Jun 2008
Externally published	Yes

Keywords

Lambert-Eaton
Neuroendocrine carcinoma nerve conduction
Repetitive nerve stimulation

ASJC Scopus subject areas

Physiology
Clinical Neurology
Cellular and Molecular Neuroscience
Physiology (medical)

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10.1002/mus.21032

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title = "Lambert-Eaton syndrome with large-cell neuroendocrine carcinoma of the lung",

abstract = "Lambert-Eaton syndrome (LES) is an immune-mediated disorder of the presynaptic neuromuscular junction due to the blocking effect of the voltage-gated calcium channel (VGCC) antibodies. Small-cell lung cancer (SCLC) is the most common cause of LES. We report an unusual case of LES associated with large-cell neuroendocrine carcinoma (LCNEC) of the lung. In this case, clinical symptoms of LES predated the diagnosis of LCNEC by 6 years. After tumor resection, the patient experienced clinical and electrophysiological improvement. In addition, he had a decrease in VGCC antibody titer from 130 to 80 pmol/L. The onset of LES can be prolonged, and tumor surveillance should continue in these cases.",

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AU - Grommes, Christian

AU - Preston, David C.

AU - Al-Kadhimi, Zaid

AU - Alshekhlee, Amer

PY - 2008/6

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AB - Lambert-Eaton syndrome (LES) is an immune-mediated disorder of the presynaptic neuromuscular junction due to the blocking effect of the voltage-gated calcium channel (VGCC) antibodies. Small-cell lung cancer (SCLC) is the most common cause of LES. We report an unusual case of LES associated with large-cell neuroendocrine carcinoma (LCNEC) of the lung. In this case, clinical symptoms of LES predated the diagnosis of LCNEC by 6 years. After tumor resection, the patient experienced clinical and electrophysiological improvement. In addition, he had a decrease in VGCC antibody titer from 130 to 80 pmol/L. The onset of LES can be prolonged, and tumor surveillance should continue in these cases.

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KW - Repetitive nerve stimulation

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Lambert-Eaton syndrome with large-cell neuroendocrine carcinoma of the lung

Abstract

Keywords

ASJC Scopus subject areas

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