Lambert-Eaton syndrome with large-cell neuroendocrine carcinoma of the lung

Christian Grommes, David C. Preston, Zaid Al-Kadhimi, Amer Alshekhlee

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Lambert-Eaton syndrome (LES) is an immune-mediated disorder of the presynaptic neuromuscular junction due to the blocking effect of the voltage-gated calcium channel (VGCC) antibodies. Small-cell lung cancer (SCLC) is the most common cause of LES. We report an unusual case of LES associated with large-cell neuroendocrine carcinoma (LCNEC) of the lung. In this case, clinical symptoms of LES predated the diagnosis of LCNEC by 6 years. After tumor resection, the patient experienced clinical and electrophysiological improvement. In addition, he had a decrease in VGCC antibody titer from 130 to 80 pmol/L. The onset of LES can be prolonged, and tumor surveillance should continue in these cases.

Original languageEnglish (US)
Pages (from-to)786-789
Number of pages4
JournalMuscle and Nerve
Issue number6
StatePublished - Jun 2008
Externally publishedYes


  • Lambert-Eaton
  • Neuroendocrine carcinoma nerve conduction
  • Repetitive nerve stimulation

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)


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