Laparoscopic transgastric esophageal mucosal resection: 4-year minimum follow-up

Constantine T. Frantzides, Mark A. Carlson, Ali Keshavarzian, Jacob E. Roberts

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Background: The management of high-grade esophageal dysplasia has included surveillance, endoscopic ablative techniques, and esophagectomy. Herein we describe an alternative treatment, laparoscopic transgastric esophageal mucosal resection. Methods: Laparoscopic transgastric esophageal mucosal resection was accomplished through an anterior gastrotomy. The mucosa was stripped from the Z-line to the proximal extent of the abnormal epithelium. The gastrotomy then was closed with a linear stapler, and a Nissen fundoplication was performed. Results: Six patients with high-grade dysplasia of the distal esophagus underwent mucosal resection. After 4 to 7 years of endoscopic surveillance, all patients have regenerated squamous epithelium. One patient developed nondysplastic Barrett's esophagus after 2 years and was treated medically. Two strictures were treated successfully with dilatation. Conclusions: Laparoscopic transgastric esophageal mucosal resection was a reasonable treatment for high-grade dysplasia in this small sample of patients. This technique is a potential alternative treatment for high-grade dysplasia of the esophagus.

Original languageEnglish (US)
Pages (from-to)305-307
Number of pages3
JournalAmerican journal of surgery
Issue number2
StatePublished - Aug 2010


  • Barrett's esophagus
  • Esophageal adenocarcinoma
  • Gastroesophageal reflux disease
  • High-grade esophageal dysplasia
  • Minimally invasive surgery
  • Mucosal ablation

ASJC Scopus subject areas

  • Surgery


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