Laparotomy attenuates lipopolysaccharide-induced gastric bleeding in the rat

Jeremy L. Ward, Benjamin A. Delano, Sasha D. Adams, Elizabeth E. Mercer, David W. Mercer

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Lipopolysaccharide (LPS) increases systemic inflammation and causes duodenogastric reflux of bile and gastric bleeding. Laparotomy prevents gastric injury from the luminal irritant bile, but its effects on LPS-induced gastric injury are unknown. We hypothesized that laparotomy would diminish inflammation and attenuate gastric bleeding caused by LPS. In the rat, laparotomy, done either before or after administration of LPS, attenuated LPS-induced bile reflux, gastric bleeding, and cyclooxygenase-2, but not inducible nitric oxide synthase, expression when compared to controls given LPS. Laparotomy also blunted LPS-induced changes in serum cytokine production. These data suggest that laparotomy has gastroprotective effects by preventing LPS-induced bile reflux and gastric bleeding and by a mechanism mediated, at least in part by cyclooxygenase-2.

Original languageEnglish (US)
Pages (from-to)902-910
Number of pages9
JournalDigestive Diseases and Sciences
Volume55
Issue number4
DOIs
StatePublished - Apr 2010

Keywords

  • COX2
  • Duodenogastric reflux
  • Laparotomy
  • Lipopolysaccharide

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

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