LEDGF, a survival factor, activates stress-related genes

Toshimichi Shinohara, Dhirendra P. Singh, Nigar Fatma

Research output: Contribution to journalReview articlepeer-review

141 Scopus citations


LEDGF is a survival factor and it enhances survival of various cell types against stress. LEDGF is also a transcriptional activator and it binds to promoter elements of heat shock and stress-related genes to activate expression of these genes. The elevated levels of the stress-related family of proteins, such as heat shock proteins, antioxidant proteins, and detoxication enzymes might suppress apoptosis induced by stress. The protective mechanisms against stress in mammalian cells and in yeast are surprisingly similar.

Original languageEnglish (US)
Pages (from-to)341-358
Number of pages18
JournalProgress in Retinal and Eye Research
Issue number3
StatePublished - 2002
Externally publishedYes


  • Heat shock element
  • Stress tolerance
  • Stress-related element
  • Survival factor
  • Transcriptional activator

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems


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