Left ventricular non-compaction in patients with single ventricle heart disease

Preeti Choudhary, Wendy Strugnell, Rajesh Puranik, Christian Hamilton-Craig, Shelby Kutty, David S. Celermajer

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Objective: Left ventricular non-compaction is an architectural abnormality of the myocardium, associated with heart failure, systemic thromboembolism, and arrhythmia. We sought to assess the prevalence of left ventricular non-compaction in patients with single ventricle heart disease and its effects on ventricular function.Methods: Cardiac MRI of 93 patients with single ventricle heart disease (mean age 24 ± 8 years; 55% male) from three tertiary congenital centres was retrospectively reviewed; 65 of these had left ventricular morphology and are the subject of this report. The presence of left ventricular non-compaction was defined as having a non-compacted:compacted (NC:C) myocardial thickness ratio >2.3:1. The distribution of left ventricular non-compaction, ventricular volumes, and function was correlated with clinical data.Results: The prevalence of left ventricular non-compaction was 37% (24 of 65 patients) with a mean of 4 ± 2 affected segments. The distribution was apical in 100%, mid-ventricular in 29%, and basal in 17% of patients. Patients with left ventricular non-compaction had significantly higher end-diastolic (128 ± 44 versus 104 ± 46 mL/m2, p = 0.047) and end-systolic left ventricular volumes (74 ± 35 versus 56 ± 35 mL/m2, p = 0.039) with lower left ventricular ejection fraction (44 ± 11 versus 50 ± 9%, p = 0.039) compared to those with normal compaction. The number of segments involved did not correlate with ventricular function (p = 0.71).Conclusions: Left ventricular non-compaction is frequently observed in patients with left ventricle-type univentricular hearts, with predominantly apical and mid-ventricular involvement. The presence of non-compaction is associated with increased indexed end-diastolic volumes and impaired systolic function.

Original languageEnglish (US)
Pages (from-to)12-18
Number of pages7
JournalCardiology in the Young
Volume30
Issue number1
DOIs
StatePublished - 2020

Keywords

  • Fontan
  • adult congenital heart disease
  • cardiac MRI
  • heart failure
  • non-compaction
  • univentricular physiology

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Cardiology and Cardiovascular Medicine

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  • Cite this

    Choudhary, P., Strugnell, W., Puranik, R., Hamilton-Craig, C., Kutty, S., & Celermajer, D. S. (2020). Left ventricular non-compaction in patients with single ventricle heart disease. Cardiology in the Young, 30(1), 12-18. https://doi.org/10.1017/S1047951119001872