TY - JOUR
T1 - Legionella pneumonia and HIV
T2 - Case reports and review of the literature
AU - Sandkovsky, Uriel
AU - Sandkovsky, Gabriel
AU - Suh, Jin
AU - Smith, Barbara
AU - Sharp, Victoria
AU - Polsky, Bruce
PY - 2008/6/1
Y1 - 2008/6/1
N2 - Although Legionnaires' disease occurs more commonly in patients with some degree of immunosuppression (diabetes, chronic lung disease, end stage renal disease, cancer, etc.), it has been infrequently described in patients infected with human immunodeficiency virus (HIV) and AIDS. Some studies suggest that pneumonia caused by Legionella tends to present with more severe clinical features and complications in the HIV-infected population. The use of antibiotic prophylaxis or the association of severe pneumonia with other pathogens may account for under diagnosis of the disease. We diagnosed five cases of Legionella pneumonia in patients with HIV infection at our institution during a 1-year period. The cases seen ranged in severity, regardless of the CD4 + counts of the patients. Based on our observations, it seems impossible to discern whether HIV infection is an additional risk factor for Legionnaires' disease. We describe those five cases and review the available literature.
AB - Although Legionnaires' disease occurs more commonly in patients with some degree of immunosuppression (diabetes, chronic lung disease, end stage renal disease, cancer, etc.), it has been infrequently described in patients infected with human immunodeficiency virus (HIV) and AIDS. Some studies suggest that pneumonia caused by Legionella tends to present with more severe clinical features and complications in the HIV-infected population. The use of antibiotic prophylaxis or the association of severe pneumonia with other pathogens may account for under diagnosis of the disease. We diagnosed five cases of Legionella pneumonia in patients with HIV infection at our institution during a 1-year period. The cases seen ranged in severity, regardless of the CD4 + counts of the patients. Based on our observations, it seems impossible to discern whether HIV infection is an additional risk factor for Legionnaires' disease. We describe those five cases and review the available literature.
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U2 - 10.1089/apc.2007.0111
DO - 10.1089/apc.2007.0111
M3 - Article
C2 - 18462074
AN - SCOPUS:47949105881
SN - 1087-2914
VL - 22
SP - 473
EP - 481
JO - AIDS Patient Care and STDs
JF - AIDS Patient Care and STDs
IS - 6
ER -