Lenalidomide oral monotherapy produces a high response rate in patients with relapsed or refractory mantle cell lymphoma

Thomas M. Habermann, Izidore S. Lossos, Glen Justice, Julie M. Vose, Peter H. Wiernik, Kyle McBride, Kenton Wride, Annette Ervin-Haynes, Kenichi Takeshita, Dennis Pietronigro, Jerome B. Zeldis, Joseph M. Tuscano

Research output: Contribution to journalArticle

210 Scopus citations

Abstract

Summary Mantle cell lymphoma (MCL) is an aggressive non-Hodgkin lymphoma with a poor prognosis following first relapse. We present a subgroup analysis of an open-label phase II trial investigating the efficacy and safety of lenalidomide in patients with relapsed or refractory MCL. Oral lenalidomide 25 mg was self-administered once daily on days 1-21 every 28 d for up to 52 weeks, according to tolerability or until disease progression. The primary endpoint was overall response rate (ORR) and secondary endpoints were duration of response, progression-free survival (PFS) and safety. Among 15 patients with MCL with a median disease duration of 5·1 years and a median of four prior treatments, the ORR was 53%. Three patients (20%) had a complete response and 5 (33%) had a partial response. The median duration of response was 13·7 months and median PFS was 5·6 months. Four of five patients who relapsed after transplantation and two of five patients who previously received bortezomib responded to lenalidomide. The most common grade 4 adverse event was thrombocytopenia (13%) and the most common grade 3 adverse events were neutropenia (40%), leucopenia (27%) and thrombocytopenia (20%). In conclusion, oral lenalidomide monotherapy is well tolerated and active in relapsed or refractory MCL.

Original languageEnglish (US)
Pages (from-to)344-349
Number of pages6
JournalBritish Journal of Haematology
Volume145
Issue number3
DOIs
StatePublished - May 2009

Keywords

  • Efficacy
  • Lenalidomide
  • Mantle cell lymphoma
  • Non-Hodgkin lymphoma
  • Safety

ASJC Scopus subject areas

  • Hematology

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    Habermann, T. M., Lossos, I. S., Justice, G., Vose, J. M., Wiernik, P. H., McBride, K., Wride, K., Ervin-Haynes, A., Takeshita, K., Pietronigro, D., Zeldis, J. B., & Tuscano, J. M. (2009). Lenalidomide oral monotherapy produces a high response rate in patients with relapsed or refractory mantle cell lymphoma. British Journal of Haematology, 145(3), 344-349. https://doi.org/10.1111/j.1365-2141.2009.07626.x