Lethal mutagenesis of HIV

Robert A. Smith; Lawrence A. Loeb; Bradley D. Preston

doi:10.1016/j.virusres.2004.11.011

Lethal mutagenesis of HIV

Robert A. Smith, Lawrence A. Loeb, Bradley D. Preston

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

HIV-1 and other retroviruses exhibit mutation rates that are 1,000,000-fold greater than their host organisms. Error-prone viral replication may place retroviruses and other RNA viruses near the threshold of "error catastrophe" or extinction due to an intolerable load of deleterious mutations. Strategies designed to drive viruses to error catastrophe have been applied to HIV-1 and a number of RNA viruses. Here, we review the concept of extinguishing HIV infection by "lethal mutagenesis" and consider the utility of this new approach in combination with conventional antiretroviral strategies.

Original language	English (US)
Pages (from-to)	215-228
Number of pages	14
Journal	Virus Research
Volume	107
Issue number	2
DOIs	https://doi.org/10.1016/j.virusres.2004.11.011
State	Published - Feb 2005
Externally published	Yes

Keywords

HIV-1
Lethal mutagenesis
Retroviruses

ASJC Scopus subject areas

Cancer Research
Virology
Infectious Diseases

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10.1016/j.virusres.2004.11.011

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title = "Lethal mutagenesis of HIV",

abstract = "HIV-1 and other retroviruses exhibit mutation rates that are 1,000,000-fold greater than their host organisms. Error-prone viral replication may place retroviruses and other RNA viruses near the threshold of {"}error catastrophe{"} or extinction due to an intolerable load of deleterious mutations. Strategies designed to drive viruses to error catastrophe have been applied to HIV-1 and a number of RNA viruses. Here, we review the concept of extinguishing HIV infection by {"}lethal mutagenesis{"} and consider the utility of this new approach in combination with conventional antiretroviral strategies.",

keywords = "HIV-1, Lethal mutagenesis, Retroviruses",

author = "Smith, {Robert A.} and Loeb, {Lawrence A.} and Preston, {Bradley D.}",

note = "Funding Information: This study was supported by Public Health Service grants CA39903 and AI42570 (L.A.L), AI34834 (B.D.P) and AI10139 (R.A.S). We thank Diana Lim for preparing the illustrations.",

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AU - Smith, Robert A.

AU - Loeb, Lawrence A.

AU - Preston, Bradley D.

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AB - HIV-1 and other retroviruses exhibit mutation rates that are 1,000,000-fold greater than their host organisms. Error-prone viral replication may place retroviruses and other RNA viruses near the threshold of "error catastrophe" or extinction due to an intolerable load of deleterious mutations. Strategies designed to drive viruses to error catastrophe have been applied to HIV-1 and a number of RNA viruses. Here, we review the concept of extinguishing HIV infection by "lethal mutagenesis" and consider the utility of this new approach in combination with conventional antiretroviral strategies.

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KW - Lethal mutagenesis

KW - Retroviruses

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Lethal mutagenesis of HIV

Abstract

Keywords

ASJC Scopus subject areas

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