Abstract
Aim: This study determined the epidemiology of developing leukemic transformation in patients with myeloproliferative neoplasms (MPN). Methods: We utilized the Surveillance, Epidemiology and End Results 13 database to identify 83 cases of leukemic transformation in MPN (n = 9335). Results: The 5-year cumulative incidence of leukemic transformation was higher in male versus female (2.17 vs 1.09%; p < 0.001), and in myelofibrosis (2.19%; 95% CI: 1.36-3.34%), compared with essential thrombocythemia (0.37%; 95% CI: 0.19-0.65%) and polycythemia vera (0.72%; 95% CI: 0.46-1.07%; p < 0.001). Patients had a median survival of 2 months after leukemic transformation, worse in older patients and without any impact of prior MPN subtypes. Conclusion: Myelofibrosis has a higher risk of leukemic transformation. Overall survival is dismal regardless of MPN subtypes.
Original language | English (US) |
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Pages (from-to) | 1239-1246 |
Number of pages | 8 |
Journal | Future Oncology |
Volume | 13 |
Issue number | 14 |
DOIs | |
State | Published - Jun 2017 |
Keywords
- acute myeloid leukemia
- hematologic/leukemia
- myeloproliferative neoplasm
- prognosis
- risk factors
- survival
ASJC Scopus subject areas
- Oncology
- Cancer Research