TY - JOUR
T1 - Lifestyle, dietary factors, and antibody levels to oral bacteria in cancer-free participants of a European cohort study
AU - Michaud, Dominique S.
AU - Izard, Jacques
AU - Rubin, Zachary
AU - Johansson, Ingegerd
AU - Weiderpass, Elisabete
AU - Tjønneland, Anne
AU - Olsen, Anja
AU - Overvad, Kim
AU - Boutron-Ruault, Marie Christine
AU - Clavel-Chapelon, Françoise
AU - Dossus, Laure
AU - Kaaks, Rudolf
AU - Katzke, Verena A.
AU - Boeing, Heiner
AU - Foerster, Jana
AU - Trichopoulou, Antonia
AU - Naska, Androniki
AU - Ziara, Giana
AU - Vineis, Paolo
AU - Grioni, Sara
AU - Palli, Domenico
AU - Tumino, Rosario
AU - Mattiello, Amalia
AU - Peeters, Petra H.M.
AU - Siersema, Peter D.
AU - Barricarte, Aurelio
AU - Huerta, José María
AU - Molina-Montes, Esther
AU - Dorronsoro, Miren
AU - Quirós, J. Ramón
AU - Duell, Eric J.
AU - Ohlsson, Bodil
AU - Jeppsson, Bengt
AU - Johansson, Anders
AU - Lif, Pernilla
AU - Khaw, Kay Tee
AU - Wareham, Nick
AU - Travis, Ruth C.
AU - Key, Tim J.
AU - Freisling, Heinz
AU - Duarte-Salles, Talita
AU - Stepien, Magdalena
AU - Riboli, Elio
AU - Bueno-De-Mesquita, H. Bas
PY - 2013/11
Y1 - 2013/11
N2 - Background: Increasing evidence suggests that oral microbiota play a pivotal role in chronic diseases, in addition to the well-established role in periodontal disease. Moreover, recent studies suggest that oral bacteria may also be involved in carcinogenesis; periodontal disease has been linked to several cancers. In this study, we examined whether lifestyle factors have an impact on antibody levels to oral bacteria. Methods: Data on demographic characteristics, lifestyle factors, and medical conditions were obtained at the time of blood sample collection. For the current analysis, we measured antibody levels to 25 oral bacteria in 395 cancer-free individuals using an immunoblot array. Combined total immunoglobin G (IgG) levels were obtained by summing concentrations for all oral bacteria measured. Results: IgG antibody levels were substantially lower among current and former smokers (1,697 and 1,677 ng/mL, respectively) than never smokers (1,960 ng/mL; p trend = 0.01), but did not vary by other factors, including body mass index, diabetes, physical activity, or by dietary factors, after adjusting for age, sex, education, country, and smoking status. The highest levels of total IgG were found among individuals with low education (2,419 ng/mL). Conclusions: Our findings on smoking are consistent with previous studies and support the notion that smokers have a compromised humoral immune response. Moreover, other major factors known to be associated with inflammatory markers, including obesity, were not associated with antibody levels to a large number of oral bacteria.
AB - Background: Increasing evidence suggests that oral microbiota play a pivotal role in chronic diseases, in addition to the well-established role in periodontal disease. Moreover, recent studies suggest that oral bacteria may also be involved in carcinogenesis; periodontal disease has been linked to several cancers. In this study, we examined whether lifestyle factors have an impact on antibody levels to oral bacteria. Methods: Data on demographic characteristics, lifestyle factors, and medical conditions were obtained at the time of blood sample collection. For the current analysis, we measured antibody levels to 25 oral bacteria in 395 cancer-free individuals using an immunoblot array. Combined total immunoglobin G (IgG) levels were obtained by summing concentrations for all oral bacteria measured. Results: IgG antibody levels were substantially lower among current and former smokers (1,697 and 1,677 ng/mL, respectively) than never smokers (1,960 ng/mL; p trend = 0.01), but did not vary by other factors, including body mass index, diabetes, physical activity, or by dietary factors, after adjusting for age, sex, education, country, and smoking status. The highest levels of total IgG were found among individuals with low education (2,419 ng/mL). Conclusions: Our findings on smoking are consistent with previous studies and support the notion that smokers have a compromised humoral immune response. Moreover, other major factors known to be associated with inflammatory markers, including obesity, were not associated with antibody levels to a large number of oral bacteria.
KW - Antibodies to oral bacteria
KW - Lifestyle factors
KW - Smoking
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U2 - 10.1007/s10552-013-0265-2
DO - 10.1007/s10552-013-0265-2
M3 - Article
C2 - 23901020
AN - SCOPUS:84886784454
SN - 0957-5243
VL - 24
SP - 1901
EP - 1909
JO - Cancer Causes and Control
JF - Cancer Causes and Control
IS - 11
ER -