Ligand-independent coactivation of peroxisome proliferator-activated receptor gamma

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


The peroxisome proliferator-activated receptors (PPARs) are related transcription factors in the nuclear hormone receptor family. The regulation of PPAR activation by ligand-dependent and ligand-independent mechanisms has been intensely studied in efforts to develop new approaches to the treatment of pathological states. In particular, PPARγ has been a focus of study due to its important roles in insulin sensitivity and adipogenesis. Since its discovery, many regulatory coactivator complexes were shown to regulate PPARγ, many of them in the absence of ligand binding. This chapter will focus on those coactivator complexes shown to activate PPARγ transcriptional activity in a ligand-independent manner.

Original languageEnglish (US)
Title of host publicationNuclear Receptors
Subtitle of host publicationThe Art and Science of Modulator Design and Discovery
PublisherSpringer International Publishing
Number of pages17
ISBN (Electronic)9783030783150
ISBN (Print)9783030783143
StatePublished - Sep 28 2021


  • CITED2
  • Ligand-independent activation
  • Mediator complex
  • P300/CREB binding protein
  • Peroxisome proliferator-activated receptor gamma
  • PGC1α
  • PPARγ
  • SWI/SNF complex

ASJC Scopus subject areas

  • General Medicine
  • General Biochemistry, Genetics and Molecular Biology


Dive into the research topics of 'Ligand-independent coactivation of peroxisome proliferator-activated receptor gamma'. Together they form a unique fingerprint.

Cite this