Ligand-independent coactivation of peroxisome proliferator-activated receptor gamma

Robert G. Bennett

doi:10.1007/978-3-030-78315-0_20

Ligand-independent coactivation of peroxisome proliferator-activated receptor gamma

Robert G. Bennett

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

The peroxisome proliferator-activated receptors (PPARs) are related transcription factors in the nuclear hormone receptor family. The regulation of PPAR activation by ligand-dependent and ligand-independent mechanisms has been intensely studied in efforts to develop new approaches to the treatment of pathological states. In particular, PPARγ has been a focus of study due to its important roles in insulin sensitivity and adipogenesis. Since its discovery, many regulatory coactivator complexes were shown to regulate PPARγ, many of them in the absence of ligand binding. This chapter will focus on those coactivator complexes shown to activate PPARγ transcriptional activity in a ligand-independent manner.

Original language	English (US)
Title of host publication	Nuclear Receptors
Subtitle of host publication	The Art and Science of Modulator Design and Discovery
Publisher	Springer International Publishing
Pages	519-535
Number of pages	17
ISBN (Electronic)	9783030783150
ISBN (Print)	9783030783143
DOIs	https://doi.org/10.1007/978-3-030-78315-0_20
State	Published - Sep 28 2021

Keywords

CITED2
Ligand-independent activation
Mediator complex
P300/CREB binding protein
Peroxisome proliferator-activated receptor gamma
PGC1α
PPARγ
SWI/SNF complex

ASJC Scopus subject areas

General Medicine
General Biochemistry, Genetics and Molecular Biology

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10.1007/978-3-030-78315-0_20

Cite this

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title = "Ligand-independent coactivation of peroxisome proliferator-activated receptor gamma",

abstract = "The peroxisome proliferator-activated receptors (PPARs) are related transcription factors in the nuclear hormone receptor family. The regulation of PPAR activation by ligand-dependent and ligand-independent mechanisms has been intensely studied in efforts to develop new approaches to the treatment of pathological states. In particular, PPARγ has been a focus of study due to its important roles in insulin sensitivity and adipogenesis. Since its discovery, many regulatory coactivator complexes were shown to regulate PPARγ, many of them in the absence of ligand binding. This chapter will focus on those coactivator complexes shown to activate PPARγ transcriptional activity in a ligand-independent manner.",

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AB - The peroxisome proliferator-activated receptors (PPARs) are related transcription factors in the nuclear hormone receptor family. The regulation of PPAR activation by ligand-dependent and ligand-independent mechanisms has been intensely studied in efforts to develop new approaches to the treatment of pathological states. In particular, PPARγ has been a focus of study due to its important roles in insulin sensitivity and adipogenesis. Since its discovery, many regulatory coactivator complexes were shown to regulate PPARγ, many of them in the absence of ligand binding. This chapter will focus on those coactivator complexes shown to activate PPARγ transcriptional activity in a ligand-independent manner.

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KW - Ligand-independent activation

KW - Mediator complex

KW - P300/CREB binding protein

KW - Peroxisome proliferator-activated receptor gamma

KW - PGC1α

KW - PPARγ

KW - SWI/SNF complex

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Ligand-independent coactivation of peroxisome proliferator-activated receptor gamma

Abstract

Keywords

ASJC Scopus subject areas

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