Linearized teixobactin is inactive and after sequence enhancement, kills methicillin-resistant Staphylococcus aureus via a different mechanism

Medicine & Life Sciences

• teixobactin 100%
• Methicillin-Resistant Staphylococcus aureus 49%
• Peptides 22%
• Nafcillin 19%
• Depsipeptides 19%
• Amino Acids 16%
• Carboxylic Acids 15%
• Isoleucine 15%
• Membranes 14%
• Threonine 13%
• Hydroxyl Radical 13%
• Gram-Positive Bacteria 13%
• Soil 12%
• Esters 12%
• Cell Wall 12%
• Penicillins 12%
• Biofilms 11%
• Electron Scanning Microscopy 11%
• Lead 10%
• Staphylococcus aureus 10%
• Kinetics 8%
• Bacteria 8%
• Anti-Bacterial Agents 7%
• Technology 7%

Engineering & Materials Science

• Staphylococcus aureus 76%
• Peptides 47%
• Amino acids 28%
• Bacteria 26%
• Membranes 20%
• Carboxylic acids 18%
• Antibiotics 17%
• Depolarization 16%
• Pathogens 16%
• Biofilms 16%
• Permeation 14%
• Esters 13%
• Linearization 11%
• Cells 11%
• Lead 11%
• Scanning electron microscopy 9%
• Soils 9%

Chemical Compounds

• Teixobactin 90%
• Peptide 20%
• Depsipeptide 16%
• Isoleucine 14%
• Penicillin 13%
• Threonine 13%
• Depolarization 13%
• Soil 10%
• Antibacterial 9%
• Carboxylic Acid 9%
• Antimicrobial Agent 8%
• Strain 8%
• Acid 8%
• Resistance 7%
• Ester 7%
• Scanning Electron Microscopy 7%