Linkage investigations of dominantly inherited diseases in man

Several large families with dominantly inherited diseases were studied. The purpose of the investigation was to determine the linkage relationships between these diseases and several other genetic markers. The disorders included in the study were spherocytosis, dominant congenital cataract, polycystic kidney disease, corneal lattice dystrophy, neurofibromatosis, Waardenberg's syndrome and Huntington's chorea. Significant linkages were found for spherocytosis and congenital cataract. Spherocytosis was found to be linked to Gm at theta=0.27. The recombination fraction was not determined between sexes. Congenital cataract was also found to be linked to Gm. When the authors' scores were added to those kindly supplied by Dr. Renwick, the linkage was significant at theta=0.07.