Lipid and polymeric carrier-mediated nucleic acid delivery

Lin Zhu, Ram I. Mahato

Research output: Contribution to journalReview articlepeer-review

94 Scopus citations


Importance of the field: Nucleic acids such as plasmid DNA, antisense oligonucleotide, and RNA interference (RNAi) molecules, have a great potential to be used as therapeutics for the treatment of various genetic and acquired diseases. To design a successful nucleic acid delivery system, the pharmacological effect of nucleic acids, the physiological condition of the subjects or sites, and the physicochemical properties of nucleic acid and carriers have to be thoroughly examined. Areas covered in this review: The commonly used lipids, polymers and corresponding delivery systems are reviewed in terms of their characteristics, applications, advantages and limitations. What the reader will gain: This article aims to provide an overview of biological barriers and strategies to overcome these barriers by properly designing effective synthetic carriers for nucleic acid delivery. Take home message: A thorough understanding of biological barriers and the structureactivity relationship of lipid and polymeric carriers is the key for effective nucleic acid therapy.

Original languageEnglish (US)
Pages (from-to)1209-1226
Number of pages18
JournalExpert Opinion on Drug Delivery
Issue number10
StatePublished - Oct 2010
Externally publishedYes


  • Lipid
  • Liposomes
  • Non-viral gene delivery
  • Nucleic acid
  • Oligonucleotides
  • Polymer
  • SiRNA

ASJC Scopus subject areas

  • Pharmaceutical Science

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