Lipid rafts, cholesterol, and the brain

Zeljka Korade, Anne K. Kenworthy

Research output: Contribution to journalReview article

178 Scopus citations

Abstract

Lipid rafts are specialized membrane microdomains that serve as organizing centers for assembly of signaling molecules, influence membrane fluidity and trafficking of membrane proteins, and regulate different cellular processes such as neurotransmission and receptor trafficking. In this article, we provide an overview of current methods for studying lipid rafts and models for how lipid rafts might form and function. Next, we propose a potential mechanism for regulating lipid rafts in the brain via local control of cholesterol biosynthesis by neurotrophins and their receptors. Finally, we discuss evidence that altered cholesterol metabolism and/or lipid rafts play a critical role in the pathophysiology of multiple CNS disorders, including Smith-Lemli-Opitz syndrome, Huntington's, Alzheimer's, and Niemann-Pick Type C diseases.

Original languageEnglish (US)
Pages (from-to)1265-1273
Number of pages9
JournalNeuropharmacology
Volume55
Issue number8
DOIs
StatePublished - Dec 2008

Keywords

  • Brain
  • Cholesterol
  • Growth factors (neurotrophins)
  • Lipid rafts
  • Myelin
  • Neurodegenerative disorders

ASJC Scopus subject areas

  • Pharmacology
  • Cellular and Molecular Neuroscience

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