Liver Cancer in Transgenic Mice Carrying the Human Immunodeficiency Virus tat Gene

Jonathan Vogel, Steven H. Hinrichs, Laura A. Napolitano, Lien Ngo, Gilbert Jay

Research output: Contribution to journalArticlepeer-review

59 Scopus citations


Patients with the acquired immunodeficiency syndrome are at risk to develop a variety of different cancers. Based on epidemiolã³gica! data, Kaposi's sarcoma and non-Hodgkin's lymphoma have been clearly asso ciated with infection by the human immunodeficiency virus (HIV). Ad ditional cancers such as basal cell and squamous cell carcinomas, mela noma, and hepatocellular carcinoma have also been reported to be asso ciated with a diagnosis of acquired immunodeficiency syndrome. A direct causal role of HIV has yet to be established for any of these cancers. We now report that transgenic mice carrying the HIV tat gene develop a high incidence of hepatocellular carcinoma after a long latency and that these changes in the liver are likely to be initiated by extrahepatic growth signals from the tat expressing cells in these mice. We predict that as acquired immunodeficiency syndrome patients begin to respond to ther apy and show prolonged survival, such “secondary” malignancies induced by HIV will become increasingly prevalent.

Original languageEnglish (US)
Pages (from-to)6686-6690
Number of pages5
JournalCancer Research
Issue number24
StatePublished - Dec 1991
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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