Liver transplantation for hepatoblastoma: The American experience

Baburao Koneru, M. Wayne Flye, Ronald W. Busuttil, Byers W. Shaw, Marc I. Lorber, Jean C. Emond, Munci Kalayoglu, Deborah K. Freese, Thomas E. Starzl

Research output: Contribution to journalArticlepeer-review

117 Scopus citations


The current role of liver transplantation in treating malignant tumors of the liver is uncertain, except for select histologic types. Pooled data on the results of liver transplantation in 12 children with hepatoblastoma is presented here. One half of the children are alive 24 to 70 (44 ± 19) months after transplantation with no evidence of recurrence. Three patients (25%) died of tumor recurrence and three (25%) died of other causes. Unifocal and intrahepatic tumors were associated with better prognosis compared to the multifocal tumors and tumors with extrahepatic spread (p = 0.04 and 0.13). Microscopically vascular invasion and the predominance of embryonal and/or anaplastic epithelium were associated with a poor prognosis compared to the tumors with no vascular invasion and with predominantly fetal epithelium (p = 0.08 and 0.1). It is concluded that continued efforts to treat unresectable hepatoblastomas by liver transplantation is justified and the role of adjuvant chemotherapy in improving the results needs to be better defined.

Original languageEnglish (US)
Pages (from-to)118-121
Number of pages4
JournalAnnals of surgery
Issue number2
StatePublished - Feb 1991
Externally publishedYes

ASJC Scopus subject areas

  • Surgery


Dive into the research topics of 'Liver transplantation for hepatoblastoma: The American experience'. Together they form a unique fingerprint.

Cite this