Background and objectives Living donor paired exchange programs assume that kidneys from living donors are of comparable quality and anticipated longevity. This study determined actual allograft t 1/2 within different recipient age groups (10-year increments) as a function of donor age (5-year increments), and juxtaposed these results against the probabilities of deceased donor transplantation, and exclusion fromtransplantation (death or removal from the wait-list). Design, setting, participants, & measurements Data from the US Renal Data System (transplant dates 1988-2003 with follow-up through September 2007)were used to determine allograft t 1/2, whereas data from patients on the United Network for Organ Sharing waiting list between 2003 and 2005 (with follow-up through February 2010) were used to determine wait-list outcomes. Results With the exception of recipients aged 18-39 years, who had the best outcomes with donors aged 18-39 years, living donor age between 18 and 64 years had minimal effect on allograft t 1/2 (difference of 1-2 yearswith no graded association). The probability of deceased donor transplantation after 3 years of wait-listing ranged from 21% to 66% by blood type and level of sensitization, whereas the probability of being excluded from transplantation ranged from 6% to 27% by age, race, and primary renal disease. Conclusions With the exception of recipients aged 18-39 years, living donor age between 18 and 64 years has minimal effect on allograft survival.
|Original language||English (US)|
|Number of pages||7|
|Journal||Clinical Journal of the American Society of Nephrology|
|State||Published - May 1 2012|
ASJC Scopus subject areas
- Critical Care and Intensive Care Medicine