Abstract
Experimental autoimmune encephalomyelitis (EAE) is an inflammatory autoimmune disease of the central nervous system which serves as a model for the human disease multiple sclerosis. We demonstrate here that encephalitogenic T cells, transduced with a retroviral gene, construct to express interleukin 4, and can delay the onset and reduce the severity of EAE when adoptively transferred to myelin basic protein-immunized mice. Thus, T lymphocytes transduced with retrovital vectors can deliver 'regulatory cytokines' in a site-specific manner and may represent a viable therapeutic strategy for the treatment of autoimmune disease.
Original language | English (US) |
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Pages (from-to) | 1711-1714 |
Number of pages | 4 |
Journal | Journal of Experimental Medicine |
Volume | 185 |
Issue number | 9 |
DOIs | |
State | Published - May 5 1997 |
Externally published | Yes |
ASJC Scopus subject areas
- General Medicine