Localization of a gene for non-syndromic hearing loss (DFNA5) to chromosome 7p15

Guy Van Camp; Paul Coucke; Wendy Balemans; Désirée Van Velzen; Caroline Van De Bilt; Lut Van Laer; Richard J.H. Smith; Kunihiro Fukushima; George W. Padberg; Rune R. Frants; Paul Van De Heyning; Shelley D. Smith; Egbert H. Huizing; Patrick J. Willems

doi:10.1093/hmg/4.11.2159

Localization of a gene for non-syndromic hearing loss (DFNA5) to chromosome 7p15

Guy Van Camp, Paul Coucke, Wendy Balemans, Désirée Van Velzen, Caroline Van De Bilt, Lut Van Laer, Richard J.H. Smith, Kunihiro Fukushima, George W. Padberg, Rune R. Frants, Paul Van De Heyning, Shelley D. Smith, Egbert H. Huizing, Patrick J. Willems

Research output: Contribution to journal › Article › peer-review

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Abstract

Progressive hearing loss affects approximately 50% of the elderly by the age of 80, and is most likely caused by an interaction of genetic and environmental factors. Identification of the genes responsible for hereditary hearing loss is therefore important. Families with pure genetic degenerative hearing disorders may be helpful as the same genes may be also involved in age-related hearing loss in general. In this study we have performed a genome search in an extended Dutch family with autosomal dominant progressive hearing loss starting in the high frequencies. The gene causing hearing loss in this family was localized to the short arm of chromosome 7, in a 15 cM interval between markers D7S493 and D7S632.

Original language	English (US)
Pages (from-to)	2159-2163
Number of pages	5
Journal	Human Molecular Genetics
Volume	4
Issue number	11
DOIs	https://doi.org/10.1093/hmg/4.11.2159
State	Published - Nov 1995
Externally published	Yes

ASJC Scopus subject areas

Molecular Biology
Genetics
Genetics(clinical)

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Camp, G. V., Coucke, P., Balemans, W., Van Velzen, D., Van De Bilt, C., Van Laer, L., Smith, R. J. H., Fukushima, K., Padberg, G. W., Frants, R. R., Heyning, P. V. D., Smith, S. D., Huizing, E. H., & Willems, P. J. (1995). Localization of a gene for non-syndromic hearing loss (DFNA5) to chromosome 7p15. Human Molecular Genetics, 4(11), 2159-2163. https://doi.org/10.1093/hmg/4.11.2159

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title = "Localization of a gene for non-syndromic hearing loss (DFNA5) to chromosome 7p15",

abstract = "Progressive hearing loss affects approximately 50% of the elderly by the age of 80, and is most likely caused by an interaction of genetic and environmental factors. Identification of the genes responsible for hereditary hearing loss is therefore important. Families with pure genetic degenerative hearing disorders may be helpful as the same genes may be also involved in age-related hearing loss in general. In this study we have performed a genome search in an extended Dutch family with autosomal dominant progressive hearing loss starting in the high frequencies. The gene causing hearing loss in this family was localized to the short arm of chromosome 7, in a 15 cM interval between markers D7S493 and D7S632.",

author = "Camp, {Guy Van} and Paul Coucke and Wendy Balemans and {Van Velzen}, D{\'e}sir{\'e}e and {Van De Bilt}, Caroline and {Van Laer}, Lut and Smith, {Richard J.H.} and Kunihiro Fukushima and Padberg, {George W.} and Frants, {Rune R.} and Heyning, {Paul Van De} and Smith, {Shelley D.} and Huizing, {Egbert H.} and Willems, {Patrick J.}",

note = "Funding Information: The authors thank Dr Hannie Kremer for helpful discussions. This study was supported by a grant from the University of Antwerp to PJW and GVC, and a grant from the Nationaal Fonds voor Wetenschappelijk Onderzoek (NFWO) to GVC. The fluorescently labeled primer set used in this study was made available free of charge by the UK Medical Research Council to GVC. GVC holds a research position with the NFWO.",

year = "1995",

month = nov,

doi = "10.1093/hmg/4.11.2159",

language = "English (US)",

volume = "4",

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AU - Camp, Guy Van

AU - Coucke, Paul

AU - Balemans, Wendy

AU - Van Velzen, Désirée

AU - Van De Bilt, Caroline

AU - Van Laer, Lut

AU - Smith, Richard J.H.

AU - Fukushima, Kunihiro

AU - Padberg, George W.

AU - Frants, Rune R.

AU - Heyning, Paul Van De

AU - Smith, Shelley D.

AU - Huizing, Egbert H.

AU - Willems, Patrick J.

N1 - Funding Information: The authors thank Dr Hannie Kremer for helpful discussions. This study was supported by a grant from the University of Antwerp to PJW and GVC, and a grant from the Nationaal Fonds voor Wetenschappelijk Onderzoek (NFWO) to GVC. The fluorescently labeled primer set used in this study was made available free of charge by the UK Medical Research Council to GVC. GVC holds a research position with the NFWO.

PY - 1995/11

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N2 - Progressive hearing loss affects approximately 50% of the elderly by the age of 80, and is most likely caused by an interaction of genetic and environmental factors. Identification of the genes responsible for hereditary hearing loss is therefore important. Families with pure genetic degenerative hearing disorders may be helpful as the same genes may be also involved in age-related hearing loss in general. In this study we have performed a genome search in an extended Dutch family with autosomal dominant progressive hearing loss starting in the high frequencies. The gene causing hearing loss in this family was localized to the short arm of chromosome 7, in a 15 cM interval between markers D7S493 and D7S632.

AB - Progressive hearing loss affects approximately 50% of the elderly by the age of 80, and is most likely caused by an interaction of genetic and environmental factors. Identification of the genes responsible for hereditary hearing loss is therefore important. Families with pure genetic degenerative hearing disorders may be helpful as the same genes may be also involved in age-related hearing loss in general. In this study we have performed a genome search in an extended Dutch family with autosomal dominant progressive hearing loss starting in the high frequencies. The gene causing hearing loss in this family was localized to the short arm of chromosome 7, in a 15 cM interval between markers D7S493 and D7S632.

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Localization of a gene for non-syndromic hearing loss (DFNA5) to chromosome 7p15

Abstract

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