Localization of a gene for non-syndromic hearing loss (DFNA5) to chromosome 7p15

Guy Van Camp, Paul Coucke, Wendy Balemans, Désirée Van Velzen, Caroline Van De Bilt, Lut Van Laer, Richard J.H. Smith, Kunihiro Fukushima, George W. Padberg, Rune R. Frants, Paul Van De Heyning, Shelley D. Smith, Egbert H. Huizing, Patrick J. Willems

Research output: Contribution to journalArticle

67 Scopus citations

Abstract

Progressive hearing loss affects approximately 50% of the elderly by the age of 80, and is most likely caused by an interaction of genetic and environmental factors. Identification of the genes responsible for hereditary hearing loss is therefore important. Families with pure genetic degenerative hearing disorders may be helpful as the same genes may be also involved in age-related hearing loss in general. In this study we have performed a genome search in an extended Dutch family with autosomal dominant progressive hearing loss starting in the high frequencies. The gene causing hearing loss in this family was localized to the short arm of chromosome 7, in a 15 cM interval between markers D7S493 and D7S632.

Original languageEnglish (US)
Pages (from-to)2159-2163
Number of pages5
JournalHuman Molecular Genetics
Volume4
Issue number11
DOIs
StatePublished - Nov 1 1995

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

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    Camp, G. V., Coucke, P., Balemans, W., Van Velzen, D., Van De Bilt, C., Van Laer, L., Smith, R. J. H., Fukushima, K., Padberg, G. W., Frants, R. R., Heyning, P. V. D., Smith, S. D., Huizing, E. H., & Willems, P. J. (1995). Localization of a gene for non-syndromic hearing loss (DFNA5) to chromosome 7p15. Human Molecular Genetics, 4(11), 2159-2163. https://doi.org/10.1093/hmg/4.11.2159