Localization of sequences within the latency-related gene of bovine herpesvirus 1 that inhibit mammalian cell growth

Vicki Geiser, Clinton Jones

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

The latency-related (LR) RNA of bovine herpes virus 1 (BHV-1) is abundantly expressed in sensory neurons of latently infected cattle. Wild-type expression of LR gene products is required for the latency-reactivation cycle. LR gene products inhibit apoptosis, bICP0 expression, and mammalian cell growth. The cell growth inhibitory function of the LR gene maps to a 463-bp XbaI-PstI fragment. Introduction of stop codons into the XbaI-PstI fragment had no effect on inhibiting growth. Expression of a LR strand-specific transcript correlates with growth inhibition in bovine fibroblasts and mouse neuroblastoma cells.

Original languageEnglish (US)
Pages (from-to)563-570
Number of pages8
JournalJournal of neurovirology
Volume11
Issue number6
DOIs
StatePublished - Dec 1 2005

Keywords

  • Bovine herpesvirus 1
  • Cell growth
  • Latency-related gene

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Virology

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