Localization of spherocytosis to chromosome 8 or 12 and report of a family with spherocytosis and a reciprocal translocation

W. J. Kimberling; T. Fulbeck; L. Dixon; H. A. Lubs

Localization of spherocytosis to chromosome 8 or 12 and report of a family with spherocytosis and a reciprocal translocation

W. J. Kimberling, T. Fulbeck, L. Dixon, H. A. Lubs

Center for Sensory Neuroscience

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Significant linkage was found between spherocytosis and a translocation involving the short arms of chromosomes 8 and 12. The gene for spherocytosis, therefore, is likely either very close to the centromere of chromosome 8 or on 12p. The unusually high frequency of spontaneous abortion in this family was probably due to this translocation and was unrelated to the spherocytosis.

Original language	English (US)
Pages (from-to)	586-594
Number of pages	9
Journal	American Journal of Human Genetics
Volume	27
Issue number	5
State	Published - 1975

ASJC Scopus subject areas

Genetics
Genetics(clinical)

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title = "Localization of spherocytosis to chromosome 8 or 12 and report of a family with spherocytosis and a reciprocal translocation",

abstract = "Significant linkage was found between spherocytosis and a translocation involving the short arms of chromosomes 8 and 12. The gene for spherocytosis, therefore, is likely either very close to the centromere of chromosome 8 or on 12p. The unusually high frequency of spontaneous abortion in this family was probably due to this translocation and was unrelated to the spherocytosis.",

author = "Kimberling, {W. J.} and T. Fulbeck and L. Dixon and Lubs, {H. A.}",

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AU - Kimberling, W. J.

AU - Fulbeck, T.

AU - Dixon, L.

AU - Lubs, H. A.

PY - 1975

Y1 - 1975

N2 - Significant linkage was found between spherocytosis and a translocation involving the short arms of chromosomes 8 and 12. The gene for spherocytosis, therefore, is likely either very close to the centromere of chromosome 8 or on 12p. The unusually high frequency of spontaneous abortion in this family was probably due to this translocation and was unrelated to the spherocytosis.

AB - Significant linkage was found between spherocytosis and a translocation involving the short arms of chromosomes 8 and 12. The gene for spherocytosis, therefore, is likely either very close to the centromere of chromosome 8 or on 12p. The unusually high frequency of spontaneous abortion in this family was probably due to this translocation and was unrelated to the spherocytosis.

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Localization of spherocytosis to chromosome 8 or 12 and report of a family with spherocytosis and a reciprocal translocation

Abstract

ASJC Scopus subject areas

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